Localization of neutral ceramidase and sphingosine kinase1 in hepatoma and breast carcinoma cells and their shed vesicles

[Optimization of systemic treatments for chronic plaque psoriasis. Recommendations for switching and transitioning.]

The aim of this study was to provide practical recommendations for optimizing the use of conventional and biological systemic treatments for moderate-severe chronic plaque psoriasis, particularly in case of transitioning and switching.A total number of 147 dermatologists from 33 different countries including Italy achieved consensus in providing practical recommendations for the use of conventional and biological treatments for moderate to severe psoriasis based on systematic literature review and/or expert opinion.In general, the continuous treatment regimen should be preferred in order to achieve a complete and long-term control of psoriasis. However, the treatment could be stopped or the…