0000000000371049
AUTHOR
M. Rubio
Regresión completa de nevos melanocíticos: correlación clínica, dermatoscópica e histológica de una serie de 13 casos
Resumen Antecedentes y objetivos La regresion completa de neoplasias melanociticas, confirmada mediante estudio histologico, se ha descrito de forma excepcional en la literatura. En esos casos es muy complicado discernir si la lesion previa era maligna o benigna, y en ocasiones tan solo la presencia o ausencia de metastasis en el seguimiento posterior del paciente permite establecer dicha distincion. Metodos Se realizo un analisis descriptivo que incluyo los nevos melanociticos extirpados en nuestro Servicio de Dermatologia en un periodo de tres anos, en los que el estudio histologico demostro una regresion completa de los mismos. Se analizaron exclusivamente aquellas lesiones de las cuales…
DNA methylomes reveal biological networks involved in human eye development, functions and associated disorders
This work provides a comprehensive CpG methylation landscape of the different layers of the human eye that unveils the gene networks associated with their biological functions and how these are disrupted in common visual disorders. Herein, we firstly determined the role of CpG methylation in the regulation of ocular tissue-specification and described hypermethylation of retinal transcription factors (i.e., PAX6, RAX, SIX6) in a tissue-dependent manner. Second, we have characterized the DNA methylome of visual disorders linked to internal and external environmental factors. Main conclusions allow certifying that crucial pathways related to Wnt-MAPK signaling pathways or neuroinflammation are…
Complete Regression of Melanocytic Nevi: Correlation Between Clinical, Dermoscopic, and Histopathologic Findings in 13 Patients
Background: The complete regression of melanocytic tumors, confirmed by histology, has rarely been reported in the literature. It is very difficult to determine the malignant or benign nature of a regressed tumor, and on occasions, the only indication of malignancy is the subsequent development of metastasis. Material and methods: We performed a descriptive study of melanocytic nevi that had undergone complete, histologically confirmed regression prior to excision in the dermatology department of our hospital over a period of 3 years. We included only lesions in which dermoscopy performed prior to regression showed features that suggested benignity. We assessed various clinical, dermoscopic…
Descriptive Dermoscopic Study of Depigmentation in Melanocytic Nevi Without a Visible Halo
Background and objectives: There are few cases described in the literature in which depigmentation of melanocytic nevi occurs without the appearance of halos. The aim of this study was to analyze the correlation between clinical and dermoscopic findings and to assess the usefulness of dermoscopy to identify possible markers of complete regression in melanocytic lesions. Materials and methods: A prospective, observational, descriptive study of 77 melanocytic lesions in 52 patients was undertaken over a 5-year period. Melanocytic lesions from patients who underwent periodic follow-up in the digital dermoscopy unit were analyzed if they had exhibited partial or total, permanent depigmentation …
Estudio descriptivo dermatoscópico de los nevos melanocíticos con despigmentación sin halo clínico
Resumen Introduccion la despigmentacion de nevos melanociticos sin halo perilesional se ha descrito de forma excepcional en la literatura. Material y metodos estudio observacional, descriptivo y prospectivo de 77 lesiones melanociticas correspondientes a 52 pacientes, llevado a cabo durante un periodo de 5 anos. Se han analizado las lesiones melanociticas de pacientes revisados periodicamente en la unidad de dermatoscopia digital que habian sufrido una despigmentacion permanente, ya fuera total o parcial, pero sin presentar clinicamente un halo blanquecino alrededor de los mismos. El objetivo fue estudiar la correlacion entre los hallazgos clinicos y dermatoscopicos a estudio, y establecer …