0000000000373350

AUTHOR

Lennart Nilsson

showing 8 related works from this author

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collabora…

2018

PubMed: 30270054

International CooperationMÉTODOS EPIDEMIOLÓGICOS030204 cardiovascular system & hematologyNationwide surveyGlobal HealthHealth Services AccessibilityDoenças Cardio e Cérebro-vascularesMOLECULAR-GENETICS0302 clinical medicineRisk FactorsPrevalenceCARDIOVASCULAR RISK-FACTORS030212 general & internal medicineCooperative BehaviorDEFECTIVE APOLIPOPROTEIN B-100GENERAL-POPULATIONeducation.field_of_studymedicine.diagnostic_testAnticholesteremic AgentsFamilial hypercholesterolaemia; FHSC; Primary dyslipidaemia; Anticholesteremic Agents; Biomarkers; Cholesterol LDL; Cooperative Behavior; Genetic Predisposition to Disease; Health Care Surveys; Health Services Accessibility; Healthcare Disparities; Humans; Hyperlipoproteinemia Type II; Phenotype; Predictive Value of Tests; Prevalence; Risk Factors; Treatment Outcome; Blood Component Removal; Global Health; International CooperationEAS Familial Hypercholesterolaemia Studies Collaboration3. Good healthPREVALENCECholesterolPhenotypeTreatment OutcomeBlood Component RemovalCORONARY-ARTERY-DISEASENATIONWIDE SURVEYCardiology and Cardiovascular MedicineFamilial hypercholesterolaemiamedicine.medical_specialtyCardiovascular risk factorsPopulationLDL-RECEPTOR1102 Cardiovascular Medicine And HaematologyLDLHyperlipoproteinemia Type II03 medical and health sciencesPredictive Value of TestsmedicineHumans:Medicine [Science]Genetic Predisposition to DiseasePrimary dyslipidaemiaHealthcare Disparitiesfhsc; familial hypercholesterolaemia; primary dyslipidaemiaeducationGenetic testingGovernmentPublic healthEAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) InvestigatorsSAFEHEART REGISTRY1103 Clinical SciencesFHSCCholesterol LDLCardiovascular System & HematologyFamily medicineHealth Care Surveys3121 General medicine internal medicine and other clinical medicineCardiovascular System & CardiologyBusinessFOLLOW-UPBiomarkers
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Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis

2014

Abstract Background The effect of climate change and its effects on vegetation growth, and consequently on rhinitis, are uncertain. Objective To examine between- and within-country associations of climate measures and the normalized difference vegetation index with intermittent and persistent rhinitis symptoms in a global context. Methods Questionnaire data from 6- to 7-year-olds and 13- to 14-year-olds were collected in phase 3 of the International Study of Asthma and Allergies in Childhood. Associations of intermittent (>1 symptom report but not for 2 consecutive months) and persistent (symptoms for ≥2 consecutive months) rhinitis symptom prevalences with temperature, precipitation, vapor…

Pulmonary and Respiratory MedicineAllergyRhinitis Allergic PerennialAdolescentClimate ChangeImmunologyEczemaClimate changeContext (language use)Normalized Difference Vegetation IndexAdolescent; Asthma; Child; Eczema; Humans; Plants; Questionnaires; Rhinitis Allergic Perennial; Rhinitis Allergic Seasonal; Climate Change; Immunology and Allergy; Pulmonary and Respiratory Medicine; Medicine (all)Interquartile rangeSurveys and QuestionnairesmedicineHumansImmunology and AllergyChildAsthmaQuestionnairebusiness.industryMedicine (all)Rhinitis Allergic SeasonalRegression analysisPlantPlantsmedicine.diseaseAsthmaConfidence intervalbusinessHumanDemographyAnnals of Allergy, Asthma & Immunology
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Familial hypercholesterolaemia: A global call to arms

2015

Familial Hypercholesterolaemia (FH) is the commonest autosomal co-dominantly inherited condition affecting man. It is caused by mutation in one of three genes, encoding the low-density lipoprotein (LDL) receptor, or the gene for apolipoprotein B (which is the major protein component of the LDL particle), or in the gene coding for PCSK9 (which is involved in the degradation of the LDL-receptor during its cellular recycling). These mutations result in impaired LDL metabolism, leading to life-long elevations in LDL-cholesterol (LDL-C) and development of premature atherosclerotic cardiovascular disease (ASCVD) [1], [2] and [3]. If left untreated, the relative risk of premature coronary artery d…

PathologyApolipoprotein BDisease030204 cardiovascular system & hematologymedicine.disease_causeGlobal HealthDISEASEDoenças Cardio e Cérebro-vasculares0302 clinical medicineHyperlipoproteinemia Type IISocieties MedicalRISK0303 health sciencesMutationbiology3. Good healthPREVALENCEEuropelipids (amino acids peptides and proteins)Cardiology and Cardiovascular MedicineFamilial hypercholesterolaemiaLife Sciences & Biomedicinemedicine.medical_specialtyHeterozygote1102 Cardiovascular Medicine And HaematologyHyperlipoproteinemia Type II03 medical and health sciencesInternal medicinemedicineHumans030304 developmental biologyScience & Technologybusiness.industryGUIDANCEPCSK9Heterozygote advantage1103 Clinical SciencesEndocrinologyPeripheral Vascular DiseaseCardiovascular System & HematologyReceptors LDLRECEPTORES DE LIPOPROTEÍNASRelative riskMutationbiology.proteinCardiovascular System & CardiologyFamilial HypercholesterolaemiabusinessCLINICIANLipoprotein
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Overweight/obesity and respiratory and allergic disease in children : international study of asthma and allergies in childhood (ISAAC) phase two

2014

Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence i…

PediatricsPulmonologyPhysiologyEpidemiologyEczemalcsh:MedicineOverweightPediatricsAtopyMedicine and Health Scienceslcsh:SciencePediatric EpidemiologyRhinitis2. Zero hungerMultidisciplinaryAllergic DiseasesAsma infantil3. Good healthPhysiological ParametersObesitatmedicine.symptomAllergy in childrenResearch Articlemedicine.medical_specialtyChildhood ObesityImmunologyPediatric PulmonologyDermatologyAl·lèrgia en els infantsChildhood obesityRespiratory infections in childrenFEV1/FVC ratioAparell respiratori MalaltiesWheezemedicineObesityAsthmaPulmonary function testsbusiness.industrylcsh:RBody WeightBiology and Life SciencesOdds ratioRhinologymedicine.diseaseAsthmaAsthma in childrenObesity in childrenOtorhinolaryngologyNasal Diseaseslcsh:QClinical ImmunologyClinical MedicinebusinessBody mass index
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Contributory presentations/posters

1999

0303 health sciencesbiologyGeneral Medicine010402 general chemistry01 natural sciencesHorseradish peroxidaseGeneral Biochemistry Genetics and Molecular Biology0104 chemical sciences03 medical and health sciencesBiochemistryManganese porphyrinbiology.proteinEnzyme reconstitutionGeneral Agricultural and Biological Sciences030304 developmental biologyJournal of Biosciences
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The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: A global synthesis

2013

This ISAAC Phase Three synthesis provides summarised information on the main findings of the study, regional tables and figures related to the prevalence and severity of current symptoms of asthma, rhinoconjunctivitis and eczema in the main regions of the world. The large number of surveyed children (≈1,200,000), the large number of centres (233) and countries (98) that participated in ISAAC Phase Three makes this study the most comprehensive survey of these diseases ever undertaken. Globally, the prevalence for current asthma, rhinoconjunctivitis and eczema in the 13-14-year age group was 14.1%, 14.6% and 7.3%, respectively. In the 6-7-year age group the prevalence for current asthma, rhin…

Pulmonary and Respiratory MedicineMalePediatricsmedicine.medical_specialtyAllergyAdolescentInternational CooperationImmunologyEczemaISAACSocioeconomic FactorSurveys and QuestionnairesEpidemiologymedicinePrevalenceHumansImmunology and AllergyPractice Patterns Physicians'ChildSocioeconomic statusChildrenRhinitiAsthmaAsthma; Children; Eczema; ISAAC; Rhinitis; Adolescent; Asthma; Child; Disease Progression; Female; Humans; International Cooperation; Male; Physician's Practice Patterns; Prevalence; Questionnaires; Socioeconomic Factors; Immunology and Allergybusiness.industryQuestionnaireDisease progressionGeneral Medicinemedicine.diseaseAsthmaSocioeconomic FactorsMulticenter studyEtiologyDisease ProgressionLocal environmentFemalePhysician's Practice PatternbusinessDemographyHuman
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A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2

2009

BACKGROUND: Common polymorphisms have been identified in genes suspected to play a role in asthma. We investigated their associations with wheeze and allergy in a case-control sample from Phase 2 of the International Study of Asthma and Allergies in Childhood. METHODS: We compared 1105 wheezing and 3137 non-wheezing children aged 8-12 years from 17 study centres in 13 countries. Genotyping of 55 candidate single nucleotide polymorphisms (SNPs) in 14 genes was performed using the Sequenom System. Logistic regression models were fitted separately for each centre and each SNP. A combined per allele odds ratio and measures of heterogeneity between centres were derived by random effects meta-ana…

Positional cloningbusiness.industryImmunologySingle-nucleotide polymorphismOdds ratiomedicine.diseaseIncreased IgE levelWheezeImmunologymedicineMS4A2Immunology and Allergymedicine.symptombusinessAllele frequencyAsthmaClinical & Experimental Allergy
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Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and …

2016

WOS: 000393031600001

PREDICTIONInternational CooperationPoolingInformation Storage and RetrievalDisease030204 cardiovascular system & hematologyGUIDELINESDoenças Cardio e Cérebro-vascularesLDL-Cholesterol0302 clinical medicineCardiovascular DiseaseMedicineData MiningCardiac and Cardiovascular Systems030212 general & internal medicineRegistriesDisease management (health)Cooperative BehaviorGENERAL-POPULATIONRISKFamilial hypercholesterolaemia ; LDL-Cholesterol ; Cardiovascular disease ; RegistryKardiologiCONSENSUS PANELDelivery of Health Care IntegratedGeneral MedicineOrvostudományokCardiovascular diseasePREVALENCE3. Good healthTreatment OutcomeCARDIOVASCULAR-DISEASEResearch DesignFamilial hypercholesterolaemiaCardiology and Cardiovascular MedicineRegistrymedicine.medical_specialtyBest practiceKlinikai orvostudományokAccess to InformationHyperlipoproteinemia Type II03 medical and health sciencesEUROPEAN ATHEROSCLEROSIS SOCIETYInternal MedicineHumansOrganizational ObjectivesBespokeStudy DesignGUIDANCEbusiness.industryPublic healthStudy designProfessional Practice GapsData sharingClinical trialCardiovascular System & Hematology3121 General medicine internal medicine and other clinical medicineFamily medicineFamilial hypercholesterolaemia; LDL-Cholesterol; Cardiovascular disease; Registry; Study design; Familial Hypercholesterolaemia Studies CollaborationFamilial Hypercholesterolaemia Studies CollaborationFamilial HypercholesterolaemiaINDIVIDUAL PARTICIPANT DATAbusiness
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