0000000000374012
AUTHOR
Benjamin Görling
Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands
The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC3F7, iC3F7, nC8F17, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear (1H, 13C, 19F, 195Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.
CCDC 993792: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 993789: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 993790: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 993788: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x
CCDC 993791: Experimental Crystal Structure Determination
Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x