6533b7dbfe1ef96bd1270171
RESEARCH PRODUCT
Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands
Judith E. SeltenreichKari RissanenMirja EndersUte SchepersLinus ReichenbachBenjamin GörlingAlexander BraunMartin NiegerStefan BräseBurkhard Luysubject
Stereochemistrychemistry.chemical_elementCrystal structure010402 general chemistry01 natural sciencesMedicinal chemistryInorganic ChemistryHeLachemistry.chemical_compoundmedicinePhysical and Theoretical ChemistryCytotoxicityta116Cisplatinbiology010405 organic chemistryArylOrganic ChemistryNuclear magnetic resonance spectroscopybiology.organism_classification3. Good health0104 chemical scienceschemistryPlatinumCyclooctadienemedicine.drugdescription
The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC3F7, iC3F7, nC8F17, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear (1H, 13C, 19F, 195Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.
year | journal | country | edition | language |
---|---|---|---|---|
2014-07-30 | Organometallics |