0000000000374014

AUTHOR

Stefan Bräse

showing 21 related works from this author

Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands

2014

The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC3F7, iC3F7, nC8F17, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear (1H, 13C, 19F, 195Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.

Stereochemistrychemistry.chemical_elementCrystal structure010402 general chemistry01 natural sciencesMedicinal chemistryInorganic ChemistryHeLachemistry.chemical_compoundmedicinePhysical and Theoretical ChemistryCytotoxicityta116Cisplatinbiology010405 organic chemistryArylOrganic ChemistryNuclear magnetic resonance spectroscopybiology.organism_classification3. Good health0104 chemical scienceschemistryPlatinumCyclooctadienemedicine.drugOrganometallics
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Single and Multiple Additions of Dibenzoylmethane onto Buckminsterfullerene

2013

A novel dibenzoylmethane-fullerene e,e,e-tris adduct was synthesized by the application of a variation of the Bingel–Hirsch conditions and characterized among others by X-ray crystallography. In addition, the corresponding hexakis adduct was detected by MALDI-TOF-MS analysis. Its existence was supported by density-functional-theory (DFT) computations. Furthermore a new synthesis of bis(benzoyl)methanofullerene was established, and its molecular structure was elucidated by X-ray crystallography. DFT computations reproduced the experimentally determined conformation and predict a low energy barrier for the rotation of the two benzoyl moieties.

FullereneDibenzoylmethane010405 organic chemistryOrganic Chemistry010402 general chemistryMass spectrometry01 natural sciences0104 chemical sciencesAdductchemistry.chemical_compoundLow energyBuckminsterfullerenechemistryComputational chemistryMoleculePhysical and Theoretical ChemistryEuropean Journal of Organic Chemistry
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Structurally diverse second-generation [2.2]paracyclophane ketimines with planar and central chirality: syntheses, structural determination, and eval…

2005

A set of 20 novel [2.2]paracyclophane ketimines with planar and central chirality has been synthesized from enantiomerically pure and racemic 5-acyl-4-hydroxy[2.2]paracyclophane and alpha-branched chiral amines. Their X-ray structures were determined to elucidate the three-dimensional structures and the absolute configuration. The ketimines were used as catalysts in the asymmetric 1,2-addition reactions of diethylzinc with substituted benzaldehydes to furnish chiral alcohols in up to 95 % ee.

chemistry.chemical_compoundPlanarChemistryStereochemistryOrganic ChemistryEnantioselective synthesisAbsolute configurationGeneral ChemistryDiethylzincChirality (chemistry)CatalysisCatalysisChemistry (Weinheim an der Bergstrasse, Germany)
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Synthesis and Topological Determination of Hexakis-Substituted 1,4-Ditritylbenzene and Nonakis-Substituted 1,3,5-Tritritylbenzene Derivatives: Buildi…

2012

Based on trityl moieties, novel organic building blocks have been prepared and structurally investigated. Substituted hexaphenyl-p-xylene (1,4-ditritylbenzene) as well as extended analogues thereof were prepared. Furthermore, a new family based on a 1,3,5-tritritylbenzene motif, connecting three trityl groups through a formal mesitylene unit, was developed. Both families were further converted through six- and nine-fold substitution reactions, respectively, to yield potent molecular building blocks for supramolecular assemblies.

Substitution reaction010405 organic chemistryStereochemistryOrganic ChemistrySupramolecular chemistry010402 general chemistry01 natural sciencesCombinatorial chemistry0104 chemical scienceschemistry.chemical_compoundchemistryPhysical and Theoretical ChemistryFamily basedMesityleneEuropean Journal of Organic Chemistry
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Single and Multiple Additions of Dibenzoylmethane onto Buckminsterfullerene (Eur. J. Org. Chem. 35/2013)

2013

chemistry.chemical_compoundBuckminsterfullereneFullerenechemistryDibenzoylmethaneComputational chemistryOrganic ChemistryOrganic chemistryPhysical and Theoretical ChemistryMass spectrometryEuropean Journal of Organic Chemistry
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Synthesis of Azido-Glycans for Chemical Glycomodification of Proteins

2018

chemistry.chemical_classificationGlycanGlycosylationbiology010405 organic chemistryChemistryStereochemistryOrganic Chemistry010402 general chemistry01 natural sciences0104 chemical scienceschemistry.chemical_compoundbiology.proteinPhysical and Theoretical ChemistryGlycoproteinEuropean Journal of Organic Chemistry
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CCDC 993792: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(cycloocta-15-diene)-dimesityl-platinum(ii)Experimental 3D Coordinates
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CCDC 949721: Experimental Crystal Structure Determination

2014

Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146

Space GroupCrystallography1-Hydroxy-3-oxo-13-diphenylprop-1-en-2-yl 4-methylbenzenesulfonateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 949723: Experimental Crystal Structure Determination

2014

Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146

Space GroupCrystallography(bis(benzoyl)methano)-C60fullereneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 993789: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1-ethylcycloocta-15-diene)-diiodo-platinum(ii)Experimental 3D Coordinates
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CCDC 1565153: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters8-(benzyloxy)-2-(4-methoxyphenyl)-6-[(4-methylphenyl)sulfanyl]hexahydro-2H-pyrano[32-d][13]dioxin-7-yl chloroacetateExperimental 3D Coordinates
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CCDC 1565150: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallography(1R2R3R4R5R)-2-[(acetyloxy)methyl]-6-azido-5-(13-dioxo-13-dihydro-2H-isoindol-2-yl)oxane-34-diyl diacetateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1565151: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallography(2S3R4R5S6R)-3-(13-dioxoisoindolin-2-yl)-2-(ethylthio)-6-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl acetateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 993790: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersdiiodo-(1-phenylcycloocta-15-diene)-platinum(ii)Experimental 3D Coordinates
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CCDC 949722: Experimental Crystal Structure Determination

2014

Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146

Space GroupCrystallographyCrystal SystemCrystal Structure2-(Dimethylsulfanylidene)-13-diphenylpropane-13-dioneCell ParametersExperimental 3D Coordinates
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CCDC 1565154: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

(2S3S4S5S6S)-45-bis(benzyloxy)-6-[(benzyloxy)methyl]-2-{[t-butyl(diphenyl)silyl]oxy}oxan-3-yl acetateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 949720: Experimental Crystal Structure Determination

2014

Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-Bromo-13-diphenylpropane-13-dioneExperimental 3D Coordinates
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CCDC 993788: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscis-dichloro-(cycloocta-15-diene)-platinum(ii)Experimental 3D Coordinates
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CCDC 993791: Experimental Crystal Structure Determination

2014

Related Article: Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse|2014|Organometallics|33|4027|doi:10.1021/om500540x

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1-methylcycloocta-15-diene)-diphenyl-platinum(ii)Experimental 3D Coordinates
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CCDC 1565152: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallographyCrystal SystemCrystal Structure{4-(acetyloxy)-5-(13-dioxo-13-dihydro-2H-isoindol-2-yl)-6-(ethylsulfanyl)-3-[(4-methoxyphenyl)methoxy]oxan-2-yl}methyl acetateCell ParametersExperimental 3D Coordinates
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CCDC 949724: Experimental Crystal Structure Determination

2014

Related Article: Alexander Giovannitti, Stefan M. Seifermann, Angela Bihlmeier, Thierry Muller, Filip Topic, Kari Rissanen, Martin Nieger, Wim Klopper, and Stefan Bräse|2013|Eur.J.Org.Chem.|2013|7907|doi:10.1002/ejoc.201301146

(bis(benzoyl)methano)-C60fullerene chloroform solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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