0000000000374419

AUTHOR

Lori Parisi

showing 2 related works from this author

Ibrutinib for the treatment of relapsed/refractory mantle cell lymphoma: extended 3.5-year follow up from a pooled analysis

2019

Oncologymedicine.medical_specialtySalvage therapyDrug resistanceLymphoma Mantle-Cellchemistry.chemical_compoundText miningPiperidinesInternal medicinemedicineHumansOnline Only ArticlesSurvival rateSalvage TherapyClinical Trials as Topicbusiness.industryAdenineHematologymedicine.diseasePrognosisLymphomaSurvival RatePyrimidineschemistryDrug Resistance NeoplasmIbrutinibRelapsed refractoryPyrazolesMantle cell lymphomaNeoplasm Recurrence LocalbusinessFollow-Up Studies
researchProduct

Long-Term Outcomes with Ibrutinib Versus the Prior Regimen: A Pooled Analysis in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL) with up to 7.5 …

2019

Introduction In MCL, progression-free survival (PFS) generally declines with each successive line of chemoimmunotherapy (CIT). We have previously published that with ibrutinib, a first-in-class oral inhibitor of Bruton's tyrosine kinase and a standard of care treatment (tx) for R/R MCL, median PFS exceeded 2 years (yrs) when used at first relapse (Rule S, et al. Haematologica. 2018;104:e211-e214). Here we present an updated pooled analysis with 15 months (mos) of additional follow-up, and for the first time, a comparison of outcomes with ibrutinib versus the prior regimen. Methods Patients (pts) enrolled in SPARK (MCL2001; NCT01599949), RAY (MCL3001; NCT01646021), and PCYC-1104 (NCT01236391…

Oncologymedicine.medical_specialtybusiness.industryImmunologyCell BiologyHematologymedicine.diseaseBiochemistryCytokine release syndromechemistry.chemical_compoundRegimenPooled analysischemistryInternal medicineIbrutinibRelapsed refractoryLong term outcomesmedicineVindesineMantle cell lymphomabusinessmedicine.drugBlood
researchProduct