0000000000377342

AUTHOR

Giuseppe Clemente

showing 8 related works from this author

Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity in…

2015

Abstract Background Adherence to a Mediterranean Diet appears to reduce the risk of cardiovascular disease, cancer, Alzheimer's disease, and Parkinson's disease, as well as the risk of death due to cardiovascular disease. No study has addressed the association between diagnostic subtype of stroke and its severity and adherence to a Mediterranean Diet in subjects with acute ischemic stroke. Aim To evaluate the association between Mediterranean Diet adherence, TOAST subtype, and stroke severity by means of a retrospective study. Methods The type of acute ischemic stroke was classified according to the TOAST criteria. All patients admitted to our ward with acute ischemic stroke completed a 137…

MaleTOAST subtypemedicine.medical_specialtySettore MED/09 - Medicina InternaMediterranean dietPopulationDiseaseDiet MediterraneanSeverity of Illness IndexBrain IschemiaBrain ischemiaMediterranean Diet scoreRisk FactorsSurveys and QuestionnairesInternal medicineSeverity of illnessmedicineHumanscardiovascular diseaseseducationStrokeAgedRetrospective Studieseducation.field_of_studyMediterranean Dietbusiness.industryRetrospective cohort studyMiddle Agedmedicine.diseaseStrokeSSS*Cardiovascular DiseasesPhysical therapyPatient ComplianceRegression AnalysisFemaleCardiology and Cardiovascular MedicinebusinessAtherosclerosis
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Stroke subtypes and their possible implication in stroke prevention drug strategies

2014

Thrombotic strokes can affect large or small arteries in the brain. Drugs to prevent atherosclerosis complication such as thrombotic strokes, should be drugs able to prevent the accumulation of intravascular fat, reduce vascular proliferation, decrease blood pressure levels with the resulting shear stress, reduce platelet aggregation, and possibly partially or totally reverse carotid plaques. Any of the commonly used antihypertensive drugs lower the incidence of stroke, with larger reductions in BP resulting in larger reductions in risk. Experimental and clinical data suggest that reducing the activity of the renin-angiotensin aldosterone system (RAAS) may have beneficial effects beyond the…

TOAST ClassificationDrugmedicine.medical_specialtySettore MED/09 - Medicina Internamedia_common.quotation_subjectBlood PressureStroke subtype preventionInternal medicinemedicineAnimalsHumanscardiovascular diseasesStrokeAntihypertensive AgentsRandomized Controlled Trials as Topicmedia_commonPharmacologyAspirinbusiness.industryDipyridamoleAtherosclerosismedicine.diseaseSurgeryStrokeDipyridamoleClinical trialBlood pressureCardiologyCardiology and Cardiovascular MedicineComplicationbusinessLipohyalinosisPlatelet Aggregation Inhibitorsmedicine.drug
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Single nucleotide polymorphisms (SNPs) of pro-inflammatory/anti-inflammatory and thrombotic/fibrinolytic genes in patients with acute ischemic stroke…

2011

Abstract Background The genetic basis of complex diseases like ischemic stroke probably consists of several predisposing risk factors, such as genes involved in inflammation and thrombotic pathways. On this basis the aim of our study was to evaluate the role of SNPs (single nucleotide polymorphisms) of some pro-inflammatory/anti-inflammatory and coagulation/fibrinolytic genes in patients with acute ischemic stroke. Methods The study population consisted of 144 consecutive Caucasian adult patients who were hospitalized in the Internal Medicine Department at the University of Palermo between November 2006 and January 2008, and who met inclusion criteria. The cases were patients admitted with …

Malemedicine.medical_specialtymedicine.medical_treatmentImmunologySingle-nucleotide polymorphismDiseaseBiochemistryPolymorphism Single NucleotideBrain IschemiaBrain ischemiaInternal medicineFibrinolysisGenotypeImmunology and AllergyMedicineSettore MED/05 - Patologia ClinicaHumansAlleleMolecular BiologyCytokineAllelesAgedDNA PrimersGeneticsAged 80 and overBase Sequencebusiness.industryFibrinolysisHaplotypeSingle nucleotide polymorphisms (SNPs)Hematologymedicine.diseaseStrokeHaplotypesAcute DiseasePopulation studyFemalebusinessCytokine
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Peripheral Frequency of CD4+ CD28- Cells in Acute Ischemic Stroke: Relationship With Stroke Subtype and Severity Markers.

2015

CD4+ CD28− T cells also called CD28 null cells have been reported as increased in the clinical setting of acute coronary syndrome. Only 2 studies previously analyzed peripheral frequency of CD28 null cells in subjects with acute ischemic stroke but, to our knowledge, peripheral frequency of CD28 null cells in each TOAST subtype of ischemic stroke has never been evaluated. We hypothesized that CD4+ cells and, in particular, the CD28 null cell subset could show a different degree of peripheral percentage in subjects with acute ischemic stroke in relation to clinical subtype and severity of ischemic stroke. The aim of our study was to analyze peripheral frequency of CD28 null cells in subjects…

RiskAcute coronary syndromemedicine.medical_specialtySettore MED/09 - Medicina InternaObservational Study5300Severity of Illness IndexArticleBrain IschemiaBrain ischemiaCD28 AntigensInternal medicineSeverity of illnessmedicineNull cellHumanscardiovascular diseasesStrokeAgedbusiness.industryCase-control studyCD28General MedicineFlow Cytometrymedicine.diseaseLymphocyte Subsetsstroke CD4+ CD28-CD4 Lymphocyte CountPeripheralStrokeCardiovascular DiseasesCase-Control StudiesPhysical therapyCardiologybusiness
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When sepsis affects the heart: A case report and literature review

2015

A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/mL. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested …

Resuscitationmedicine.medical_specialtyMyocarditisbusiness.industryCardiogenic shockCase ReportGeneral Medicinemedicine.diseasePulmonary embolismSurgerySepsisInternal medicineShock (circulatory)medicineCardiologyMyocardial infarctionmedicine.symptomTransthoracic echocardiogrambusiness
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Immune-inflammatory and metabolic effects of high dose furosemide plus hypertonic saline solution (HSS) treatment in cirrhotic subjects with refracto…

2016

Introduction Patients with chronic liver diseases are usually thin as a result of hypermetabolism and malnutrition expressed by reduced levels of leptin and impairment of other adyponectins such as visfatin. Aims We evaluated the metabolic and inflammatory effects of intravenous high-dose furosemide plus hypertonic saline solutions (HSS) compared with repeated paracentesis and a standard oral diuretic schedule, in patients with cirrhosis and refractory ascites. Methods 59 consecutive cirrhotic patients with refractory ascites unresponsive to outpatient treatment. Enrolled subjects were randomized to treatment with intravenous infusion of furosemide (125-250mg⁄bid) plus small volumes of HSS …

Liver CirrhosisMaleLeptinCirrhosisPhysiologyPeptide Hormonesmedicine.medical_treatmentdiureticlcsh:MedicineVisfatinPathology and Laboratory MedicineFurosemide; Hypertonic Saline Solution; TNF-alpha; IL-1beta; IL-6; ANP; BNP; Visfatin; Leptin; cirrhosis; refractory ascites; paracentesis; diureticBiochemistryGastroenterology0302 clinical medicineRecurrenceFurosemideImmune PhysiologyMedicine and Health SciencesParacentesisDiureticslcsh:ScienceImmune ResponseSalineHypertonicInnate Immune SystemMultidisciplinarymedicine.diagnostic_testLiver DiseasesPhysicsLeptinrefractory asciteAscitesClassical MechanicsFurosemideHematologyMiddle AgedBody FluidsBloodTreatment OutcomeCirrhosis030220 oncology & carcinogenesisPhysical SciencesHypermetabolismCytokinesAdministration IntravenousFemale030211 gastroenterology & hepatologyAnatomyInflammation MediatorsANPResearch ArticleTNF-alphamedicine.drugparacentesimedicine.medical_specialtyInflammatory DiseasesImmunologyGastroenterology and HepatologyBlood Plasma03 medical and health sciencesSigns and SymptomsDiagnostic MedicineOsmotic PressureInternal medicinePressuremedicineTonicityHumansAgedInflammationSaline Solution HypertonicIL-6business.industrylcsh:RBiology and Life SciencesMolecular DevelopmentIL-1betamedicine.diseaseHormonesHypertonic salineEndocrinologyImmune Systemlcsh:QHypertonic Saline SolutionDiureticbusinessBiomarkersDevelopmental BiologyBNPcirrhosi
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HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke

2019

Abstract Introduction In humans, a major component of natural killer (NK) and T cell target recognition depends on the surveillance of human leukocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Aims To implement the knowledge about the immunological genetic background of acute ischemic stroke susceptibility in relation to the frequency of the KIR genes and HLA alleles. Methods Subjects with acute ischemic stroke and subjects without stroke were genotyped for the presence of KIR genes and of the three major KIR ligand groups, HLA-C1, HLA-C2, and HLA-Bw4, both HLA-B and HLA-A loci. Results Between November 2013 and February 2016, consecutive patients with …

MaleKiller immunoglobulin-like receptors (KIRs)0301 basic medicinemedicine.medical_specialtySettore MED/09 - Medicina InternaNeurologyGenotypeT cellKIR LigandImmunologyKiller-cell immunoglobulin-like receptorchemical and pharmacologic phenomenaHuman leukocyte antigenlcsh:RC346-429Proinflammatory cytokine03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineReceptors KIRotorhinolaryngologic diseasesHumansMedicineGenetic Predisposition to DiseaseReceptorStrokelcsh:Neurology. Diseases of the nervous systemAgedSettore MED/04 - Patologia GeneraleNeuroscience (all)business.industryResearchGeneral NeuroscienceHistocompatibility Antigens Class IMiddle Agedmedicine.diseaseStrokeHLACross-Sectional Studies030104 developmental biologymedicine.anatomical_structureNeurologyImmunologyFemalebusiness030217 neurology & neurosurgeryJournal of Neuroinflammation
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HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute viral encephalitis

2018

// Antonino Tuttolomondo 1 , Claudia Colomba 2 , Danilo Di Bona 6 , Alessandra Casuccio 4 , Domenico Di Raimondo 1 , Giuseppe Clemente 1 , Valentina Arnao 5 , Rosaria Pecoraro 1 , Paolo Ragonese 5 , Anna Aiello 3 , Giulia Accardi 3 , Rosario Maugeri 5 , Carlo Maida 1 , Irene Simonetta 1 , Vittoriano Della Corte 1 , Domenico Gerardo Iacopino 5 , Calogero Caruso 3 , Antonio Cascio 2 and Antonio Pinto 1 on behalf of KIRIIND (KIR Infectious and Inflammatory Diseases) Collaborative Group 1 U.O.C di Medicina Interna con Stroke Care, Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), Universita degli Studi di Palermo, Palermo, Italy 2 U.O.C di Malattie Infettive, Dipartiment…

0301 basic medicineSettore MED/09 - Medicina InternaencephalitisKiller-cell immunoglobulin-like receptorHuman leukocyte antigenAcute viral encephalitis03 medical and health sciences0302 clinical medicineEncephalitimedicineIn patientGenotypingSettore MED/04 - Patologia Generalebusiness.industryHaplotypemedicine.diseaseVirologyKIRHLA030104 developmental biologyEncephalitis; HLA; KIRs; OncologyOncologybusinessKIR3DL1KIRs030217 neurology & neurosurgeryEncephalitisResearch Paper
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