0000000000380751
AUTHOR
Eudald Carbonell
Vegetation and climate record from Abric Romaní (Capellades, northeast Iberia) during the Upper Pleistocene (MIS 5d−3)
This study addresses the pollen record of Abric Romani archaeological site and the climate evolution of the last interglacial and glacial stadials in the Iberian Peninsula. The new pollen record spans the interval from 110,000 to 55,000 years ago. In general, the glacial/stadial vegetation is characterized by a steppe and herbaceous communities indicating dry and cold climatic conditions, whereas the vegetation optimum of past interglacials can be described as pine-oaks with mediterranean forest indicating milder and moister climatic conditions. During the first half of the MIS 5a and the MIS 5c, the region was warmer, which is characterized by temperate forests. However, the existence of A…
Acid–base behaviour and binding to double stranded DNA/RNA of benzo[g]phthalazine-based ligands
The affinity and the binding mode of two benzo[g]phthalazine compounds, functionalized with one or two 2-(imidazole-4-yl)-ethylamine groups, to DNA and RNA models have been evaluated by means of UV-Vis, fluorescence and circular dichroism (CD) spectroscopies in combination with viscometry and molecular dynamics. Both organic molecules bind strongly to all nucleic acid models via the intercalation mode in the duplex structure, especially compound 1. Intriguingly, 1 exhibits different emission responses depending on the base composition of duplex DNA/RNAs, which points out the possibility of using it as a base selective nucleic acid probe. Moreover, the acid-base behaviour of both compounds h…
Genome-wide patterns of selection in 230 ancient Eurasians
Mathieson, Iain et al.