0000000000382410
AUTHOR
Stephan Collins
showing 4 related works from this author
Impact des rythmes circadiens sur l'exocytose des granules d'insuline
2015
Impact des rythmes circadiens sur l'exocytose des granules d'insuline. congrès de la société francophone du Diabète (SFD)
WD40-repeat 47 is essential for brain development via microtubule-mediated processes and autophagy
2017
Erreur dates et n° de conférence dans l'url https://hal.archives-ouvertes.fr/hal-02378786.; International audience
Alteration of hypothalamic glucose and lactate sensing in 48h hyperglycemic rats.
2013
International audience; Hypothalamic detection of nutrients is involved in the control of energy metabolism and is altered in metabolic disorders. Although hypothalamic detection of blood lactate lowers hepatic glucose production and food intake, it is unknown whether it also modulates insulin secretion. To address this, a lactate injection via the right carotid artery (cephalad) was performed in Wistar rats. This triggered a transient increase in insulin secretion. Rats made hyperglycemic for 48h exhibited prolonged insulin secretion in response to a glucose injection via the carotid artery, but lactate injection induced two types of responses: half of the HG rats showed no difference comp…
Glucose and hypothalamic astrocytes: More than a fueling role?
2015
Brain plays a central role in energy homeostasis continuously integrating numerous peripheral signals such as circulating nutrients, and in particular blood glucose level, a variable that must be highly regulated. Then, the brain orchestrates adaptive responses to modulate food intake and peripheral organs activity in order to achieve the fine tuning of glycemia. More than fifty years ago, the presence of glucose-sensitive neurons was discovered in the hypothalamus, but what makes them specific and identifiable still remains disconnected from their electrophysiological signature. On the other hand, astrocytes represent the major class of macroglial cells and are now recognized to support an…