0000000000384247
AUTHOR
Javier Ortiz
Estrategias de comunicación para la divulgación de la I+D+i
Este e-book es el fruto de una serie de talleres centrados en la promoción de la innovación realizados gracias a la iniciativa, el impulso y la dirección de la Fundació Parc Cientific Universitat de València (FPCUV). El conjunto de estas actividades se enmarca en el programa COMUNICA-INNOVA[ción] 2020, promovido por la FPCUV y financiado por la Conselleria d’Innovació, Universitats, Ciència i Societat Digital de la Generalitat Valenciana. Este programa persigue un doble objetivo. Por una parte, el establecimiento de una comunicación directa del personal investigador y emprendedor del Parc Científic con profesionales de la información, especialmente científica y económica; y, por otra, la ad…
The transcriptome of Echinostoma caproni adults: further characterization of the secretome and identification of new potential drug targets.
Abstract Echinostomes are cosmopolitan parasites that infect a large number of different warm-blooded hosts, both in nature and in the laboratory. They also constitute an important group of food-borne trematodes of public health importance mainly in Southeast Asia and the Far East. In addition, echinostomes are an ideal model to study several aspects of intestinal helminth biology, since they present a number of advantages. For example, echinostomes are large worms whose life cycle is relatively easy to maintain in the laboratory. Recently, several studies documented their great value in the study of intestinal helminth–vertebrate host relationship. Detailed knowledge of their genome, trans…
A Sliding Window-Based Method to Detect Selective Constraints in Protein-Coding Genes and Its Application to RNA Viruses
Here we present a new sliding window-based method specially designed to detect selective constraints in specific regions of a multiple protein-coding sequence alignment. In contrast to previous window-based procedures, our method is based on a nonarbitrary statistical approach to find the appropriate codon-window size to test deviations of synonymous (d(S)) and nonsynonymous (d(N)) nucleotide substitutions from the expectation. The probabilities of d(N) and d(S) are obtained from simulated data and used to detect significant deviations of d(N) and d(S) in a specific window region of the real sequence alignment. The nonsynonymous-to-synonymous rate ratio (w = d(N)/d(S)) was used to highlight…
The transcriptome analysis of Strongyloides stercoralis L3i larvae reveals targets for intervention in a neglected disease.
Background: Strongyloidiasis is one of the most neglected diseases distributed worldwide with endemic areas in developed countries, where chronic infections are life threatening. Despite its impact, very little is known about the molecular biology of the parasite involved and its interplay with its hosts. Next generation sequencing technologies now provide unique opportunities to rapidly address these questions. Principal Findings: Here we present the first transcriptome of the third larval stage of S. stercoralis using 454 sequencing coupled with semi-automated bioinformatic analyses. 253,266 raw sequence reads were assembled into 11,250 contiguous sequences, most of which were novel. 8037…