Rate capability of a cryogenic stopping cell for uranium projectile fragments produced at 1000 MeV/u

At the Low-Energy Branch (LEB) of the Super-FRS at FAIR, projectile and fission fragments will be produced at relativistic energies, separated in-flight, energy-bunched, slowed down and thermalized in a cryogenic stopping cell (CSC) filled with ultra-pure He gas. The fragments are extracted from the stopping cell using a combination of DC and RF electric fields and gas flow. A prototype CSC for the LEB has been developed and successfully commissioned at the FRS Ion Catcher at GSI. Ionization of He buffer gas atoms during the stopping of energetic ions creates a region of high space charge in the stopping cell. The space charge decreases the extraction efficiency of stopping cells since the …

Empirical Mode Decomposition on Mismatch Negativity

Empirical mode decomposition (EMD) has been applied in the various disciplines to extract the desired signal. The basic principle is to decompose a time series into intrinsic mode functions (IFMs) and each IFM corresponds to an oscillation phenomenon. A statistical description of the oscillatory activities of the EEG has been well known. It is desired to extract single oscillatory process from the EEG by EMD. Mismatch negativity (MMN) can be automatically elicited by the deviant stimulus in an oddball paradigm, in which physically the deviant stimulus occurs among repetitive and homogeneous stimuli. MMN thus reflects the ability of the brain to detect changes in auditory stimuli. So, the MM…

Parent of origin effects in attention/deficit hyperacticvity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program

Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GA…

First spatial separation of a heavy ion isomeric beam with a multiple-reflection time-of-flight mass spectrometer

Physics letters / B 744, 137 - 141 (2015). doi:10.1016/j.physletb.2015.03.047

Characterizing diversity in the tumor-immune microenvironment of distinct subclasses of gastroesophageal adenocarcinomas

Background Gastroesophageal adenocarcinomas (GEAs) are heterogeneous cancers where immune checkpoint inhibitors have robust efficacy in heavily inflamed microsatellite instability (MSI) or Epstein-Barr virus (EBV)-positive subtypes. Immune checkpoint inhibitor responses are markedly lower in diffuse/genome stable (GS) and chromosomal instable (CIN) GEAs. In contrast to EBV and MSI subtypes, the tumor microenvironment of CIN and GS GEAs have not been fully characterized to date, which limits our ability to improve immunotherapeutic strategies. Patients and methods Here we aimed to identify tumor-immune cell association across GEA subclasses using data from The Cancer Genome Atlas (N = 453 GE…

Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one

High-resolution, accurate MR-TOF-MS for short-lived, exotic nuclei of few events in their ground and low-lying isomeric states

Mass measurements of fission and projectile fragments, produced via $^{238}$U and $^{124}$Xe primary beams, have been performed with the multiple-reflection time-of-flight mass spectrometer (MR-TOF-MS) of the FRS Ion Catcher with a mass resolving powers (FWHM) up to 410,000 and an uncertainty of $6\cdot 10^{-8}$. The nuclides were produced and separated in-flight with the fragment separator FRS at 300 to 1000 MeV/u and thermalized in a cryogenic stopping cell. The data-analysis procedure was developed to determine with highest accuracy the mass values and the corresponding uncertainties for the most challenging conditions: down to a few events in a spectrum and overlapping distributions, ch…

Concatenated trial based Hilbert-Huang transformation on event-related potentials

Time-frequency analysis is critical to study event-related potentials (ERPs) now. ERPs are usually generated through averaging over a number of trials, and such averaging limits the application of a nonlinear time-frequency analysis method—Hilbert-Huang transformation (HHT). This is because HHT usually requires very long recordings to sufficiently decompose the complicated signal into oscillations and the averaged ERP trace tends to possess only hundreds of samples. Thus, this study designs the concatenated trial based HHT to release the limitation on the decomposition. Such a paradigm may reveal better temporal and spectral properties of an ERP than the conventional wavelet transformation …

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

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