0000000000385619

AUTHOR

Christopher Patterson

showing 3 related works from this author

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

2016

Abstract Aims Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men. Methods Baseline serum levels of leptin and adiponectin were measured in 1839 non-diabetic men aged 50–60 years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7 years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general prac…

LeptinMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismPopulationAdipokine030209 endocrinology & metabolismType 2 diabetes030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineEndocrinologyWaist–hip ratioSDG 3 - Good Health and Well-beingRisk FactorsDiabetes mellitusInternal medicineInternal MedicineHumansMedicineProspective StudieseducationProspective cohort studyProportional Hazards Modelseducation.field_of_studyAdiponectinbusiness.industryIncidenceHazard ratioGeneral MedicineMiddle Agedmedicine.diseaseUnited KingdomC-Reactive ProteinEndocrinologyDiabetes Mellitus Type 2/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingAdiponectinbusinessBiomarkersDiabetes Research and Clinical Practice
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

2012

BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. METHODS: We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls). Se…

LOCIMyocardial Infarction030204 cardiovascular system & hematologychemistry.chemical_compound0302 clinical medicineHigh-density lipoproteinGene Frequencyplasma HDL cholesterol ; mendelian randomisation ; MIHDL cholesterolsingle nucleotide polymorphismRisk FactorsGENETIC-VARIANTSARTERY-DISEASEProspective StudiesMyocardial infarction0303 health sciencesHDL cholesterol; myocardial infarction; single nucleotide polymorphismISCHEMIC CARDIOVASCULAR-DISEASEGeneral Medicine3. Good healthCardiologylipids (amino acids peptides and proteins)medicine.medical_specialtyDalcetrapibSingle-nucleotide polymorphismPolymorphism Single Nucleotide03 medical and health sciencesInternal medicinemedicineHumansCORONARY-HEART-DISEASEGenetic Predisposition to DiseaseMETAANALYSIS030304 developmental biologyBLOOD CHOLESTEROLbusiness.industryCholesterolCholesterol HDLCase-control studyCholesterol LDLLipaseOdds ratioMendelian Randomization Analysismedicine.diseaseENDOTHELIAL LIPASEATHEROSCLEROSISchemistryCase-Control StudiesbusinessHIGH-DENSITY-LIPOPROTEINBiomarkersEvacetrapibThe Lancet
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Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium

2016

AIMS: Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to evaluate the improved eligibility for statin therapy based on elevated troponin I concentrations retrospectively.METHODS AND RESULTS: Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective population-based studies including 74 738 participants. We investigated the value of adding troponin …

Relative risk reductionPathologymedicine.medical_specialtyBIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICAPopulationBiomarker For Cardiovascular Risk Assessment In Europe ; Cardiovascular Risk ; High-sensitivity Assayed Troponin I ; Monica Risk Genetics Archiving And Monograph ; Mortality030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingInternal medicineTroponin IMedicineRosuvastatin030212 general & internal medicineMortalityeducationBiomarker for Cardiovascular Risk Assessment in Europe; Cardiovascular risk; High-sensitivity assayed troponin I; MONICA Risk Genetics Archiving and Monograph; Mortalityeducation.field_of_studyFramingham Risk Scorebiologybusiness.industryHazard ratioAbsolute risk reductionBiomarker for Cardiovascular Risk Assessment in EuropeCardiovascular riskMONICA Risk Genetics Archiving and MonographTroponinHigh-sensitivity assayed troponin I3. Good healthCardiologybiology.protein/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingCardiology and Cardiovascular Medicinebusinessmedicine.drugEuropean Heart Journal
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