0000000000386782

AUTHOR

Renda M.

showing 3 related works from this author

La psicologia scientifica francese nella storia de "L'Année Psychologique"

2005

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Search for Magnetic Monopoles and Stable High-Electric-Charge Objects in 13 Tev Proton-Proton Collisions with the ATLAS Detector

2020

We thank CERN for the very successful operation of the LHC, aswell as the support staff fromour institutionswithout whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; FWF, BMWFW, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq, FAPESP, Brazil; NSERC, CFI, NRC, Canada; CERN; CONICYT, Chile; CAS, NSFC, MOST, China; COLCIENCIAS, Colombia; VSC CR, MSMT CR, MPO CR, Czech Republic; DNSRC, DNRF, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; MPG, HGF, BMBF, Germany; GSRT, Greece; RGC, Hong Kong SAR, Hong Kong China; Benoziyo Center, ISF, Israel; INFN, Italy; JSPS, MEXT, Japan; JINR; CNRST, Morocco; NWO, Nether…

electric [charge]Drell-Yan process:Kjerne- og elementærpartikkelfysikk: 431 [VDP]Magnetic monopolesProton13000 GeV-cmsPhysics::Instrumentation and Detectorselectromagnetic [calorimeter]magnetic [charge]General Physics and Astronomy7. Clean energy01 natural scienceschannel cross section: upper limitHigh Energy Physics - Experimentmagnetic monopole: massSubatomär fysikparticle: stabilityHigh Energy Physics - Experiment (hep-ex)magnetic monopole: pair productionSubatomic Physicsscattering [p p][PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]tracking detectorstability [particle]0 [spin]1/2 [spin]Particle productionHadron collidersPhysicsRange (particle radiation)Large Hadron Colliderupper limit [channel cross section]DetectorSettore FIS/01 - Fisica Sperimentalemass [magnetic monopole]ATLAS3. Good health:Nuclear and elementary particle physics: 431 [VDP]CERN LHC Collhigh [ionization]ATLAS Detectorslower limit [mass]atlas; lhc; higgs;colliding beams [p p]pair production [magnetic monopole]Particle Physics - ExperimentsignatureDirect Productionp p: scatteringHigh-Ionizationdirect production [magnetic monopole]530 PhysicsCiências Naturais::Ciências Físicasmass: lower limit:Ciências Físicas [Ciências Naturais]Magnetic monopolespin: 0FOS: Physical sciencesLHC ATLAS High Energy Physicsddc:500.2Electromagnetic CalorimeterElectric chargeComputer Science::Digital LibrariesChargeNuclear physicsionization: high0103 physical sciencesTransition Radiation Trackersddc:530High Energy Physicsspin: 1/2010306 general physicsCiencias ExactasATLAS Collaborationcharge: magneticmagnetic monopolesS028CScience & Technologyhep-excharge: electricFísicaCharge (physics)triggerPair productioncalorimeter: electromagneticProton Proton CollisionsExperimental High Energy PhysicsMagnetic ChargesElementary Particles and FieldsHigh Energy Physics::Experimenttransition radiationHadron-hadron collisionsp p: colliding beamsmagnetic monopole: direct productionexperimental resultsPhysical Review Letters
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Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel

2023

AbstractF508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacological correctors, such as VX-809 and VX-445, that stabilize CFTR and improve its trafficking to plasma membrane. Using a functional test to evaluate a panel of chemical compounds, we have identified tricyclic pyrrolo-quinolines as novel F508del correctors with high efficacy on primary airway epithelial cells from CF patients. The most effective compound, PP028, showed synergy when combined with VX-809 and VX-661 but not with VX-445. By testing the …

Multidisciplinarypyrrolo‑quinolinesCFTRSettore CHIM/08 - Chimica FarmaceuticaCystic fibrosisScientific Reports
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