La psicologia scientifica francese nella storia de "L'Année Psychologique"

Search for Magnetic Monopoles and Stable High-Electric-Charge Objects in 13 Tev Proton-Proton Collisions with the ATLAS Detector

We thank CERN for the very successful operation of the LHC, aswell as the support staff fromour institutionswithout whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; FWF, BMWFW, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq, FAPESP, Brazil; NSERC, CFI, NRC, Canada; CERN; CONICYT, Chile; CAS, NSFC, MOST, China; COLCIENCIAS, Colombia; VSC CR, MSMT CR, MPO CR, Czech Republic; DNSRC, DNRF, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; MPG, HGF, BMBF, Germany; GSRT, Greece; RGC, Hong Kong SAR, Hong Kong China; Benoziyo Center, ISF, Israel; INFN, Italy; JSPS, MEXT, Japan; JINR; CNRST, Morocco; NWO, Nether…

Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel

AbstractF508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacological correctors, such as VX-809 and VX-445, that stabilize CFTR and improve its trafficking to plasma membrane. Using a functional test to evaluate a panel of chemical compounds, we have identified tricyclic pyrrolo-quinolines as novel F508del correctors with high efficacy on primary airway epithelial cells from CF patients. The most effective compound, PP028, showed synergy when combined with VX-809 and VX-661 but not with VX-445. By testing the …