0000000000387330
AUTHOR
Estelle Pujos-guillot
DHA dose-dependently reduces atherosclerosis: a putative role for its peroxidation metabolites, F4-Neuroprostanes
International audience
Can we Trust Untargeted Metabolomics: Results of the Metabo-ring Initiative, a Large-scale Multi-instruments Inter-laboratoire Study
This work was presented at the 6th Journée Scientifique du Réseau Français de Métabolomique et Fluxomique, Nantes, May 2012 and at the 8th International Conference of the Metabolomics Society, Washington, June 2012This work was presented at the 6th Journée Scientifique du Réseau Français de Métabolomique et Fluxomique, Nantes, May 2012 and at the 8th International Conference of the Metabolomics Society, Washington, June 2012; The metabo-ring initiative brought together five nuclear magnetic resonance instruments (NMR) and 11different mass spectrometers with the objective of assessing the reliability of untargeted metabolomics approaches in obtaining comparable metabolomics profiles. This wa…
La teneur hépatique en F4-Neuroprostanes : une variable prédictive majeure de la réduction de la plaque d’athérome
Le fichier annexe contient le livre des résumés; Les propriétés athéroprotectrices des acides gras polyinsaturés de type n-3 à longue chaîne (AGPI n-3 LC), et en particulier de l’acide docosahexaénoique (DHA) ont été largement décrites. Néanmoins, les mécanismes d’action restent encore mal connus. Les recherches se sont récemment orientées vers l’identification des métabolites oxygénés issus des AGPI n-3 LC qui sont de plus en plus considérés comme des effecteurs majeurs de leurs effets athéroprotecteurs. Dans ce contexte, une étude dose-réponse de supplémentation en DHA a été réalisée chez un modèle animal d’athérosclérose (souris LDLR-/-) afin d’étudier les relations entre la progression …
The paradox of omega 3 PUFAs: autoprotection although highly susceptible to peroxidation
National audience
Anti-atherogenic action of DHA in LDLR-/- mice: are DHA oxygenated metabolites players in the resolution of inflammation?
National audience
An Early Stage Researcher's Primer on Systems Medicine Terminology
Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. Thes…
Atheroprotective effects and peroxidation of docosahexaenoic acid: is there a direct link?
International audience
Lipid profiling following intake of the Omega 3 fatty acid DHA identifies the peroxidized metabolites F-4-Neuroprostanes as the best predictors of atherosclerosis prevention
International audience; The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediat or profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 fatty acids. The present study aimed to determine the impact of DHA supplementation on the profiles of polyunsaturated fatty acids (PUFA) oxygenated metabolites and to investigate their contribution to therosclerosis prevention. A special emphasis was given to the non-enzymatic metabolites knowing the high susceptibility of DHA to free radical…