0000000000388468
AUTHOR
F. Vicente-pedrós
DC polarographic reduction of chloroguanide hydrochloride.
Chloroguanide hydrochloride, an antimalarial drug, shows one well-defined DC polarographic wave in Britton-Robinson buffered media. In the pH range 3–9 the observed reduction wave is related to the reduction of the two azomethine centers on the monoprotonated biguanide group (BH+). The effects of pH and other experimental variables on the limiting current and half-wave potentials as well as the reduction mechanism are discussed.
Antidiabetic Behavior of Biguanides
The existence of active electron pairs on some nitrogen atoms in phenformin hydrochloride is inferred from the presence of a hydrogen catalytic polarographic wave. This finding emphasizes the ability of biguanides to form hydrogen bridges with other molecular species such as amino acids and proteins, as well as to form coordination complexes with zinc and other metallic cations by means of these electron pairs. The antidiabetic action of phenformin and other related biguanides can be explained in terms of competition between these molecules and insulin to coordinate cationic oligoelements together with their ability to form hydrogen bonds between the biguanide moiety and insulin itself.