6533b7dcfe1ef96bd1271e9b
RESEARCH PRODUCT
DC polarographic reduction of chloroguanide hydrochloride.
F. Vicente-pedrósF. Tomás-vertJ. Vera-sánchezsubject
PolarographyBiguanidemedicine.drug_classChemistryProguanil HydrochlorideInorganic chemistryLimiting currentPharmaceutical ScienceDimethylformamideHydrogen-Ion ConcentrationReduction (complexity)DiffusionProguanilPh rangemedicineOxidation-ReductionPolarographydescription
Chloroguanide hydrochloride, an antimalarial drug, shows one well-defined DC polarographic wave in Britton-Robinson buffered media. In the pH range 3–9 the observed reduction wave is related to the reduction of the two azomethine centers on the monoprotonated biguanide group (BH+). The effects of pH and other experimental variables on the limiting current and half-wave potentials as well as the reduction mechanism are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1984-12-01 | Journal of pharmaceutical sciences |