0000000000388494
AUTHOR
Ursula Gundert-remy
Risk assessment of Bundeswehr (German Federal Armed Forces) permethrin-impregnated battle dress uniforms (BDU).
In an age when vector-borne diseases are emerging worldwide, personal protective measures are essential for shielding soldiers and other exposed persons from arthropod attack. The development of permethrin-impregnated clothing has been one recent advance in protecting persons at-risk. However, to date risk assessment has not been performed related to wearing permethrin-impregnated clothing over longer time periods. Therefore, this paper describes relevant toxicological aspects of permethrin and estimates the extent of dermal permethrin uptake by soldiers wearing impregnated uniforms by determining urine metabolites of permethrin. The exposure monitoring conducted in wearers of untreated uni…
Optimization of curation of the dataset with data on repeated dose toxicity
Introduction: For some areas of risk assessment, the use of alter-native methods is supported by current directives and guidance(e.g. REACH, Cosmetics, BPD, PPP). According to OECD principles alternative methods need to be scientifically valid. Methods: Within a project on grouping and development of predictive models sup-ported by a grant of Federal Ministry of Education and Research, we curated a dataset based on RepDose and ELINCS database. The final dataset consists of rat repeated dose toxicity studies for 1022 com-pounds representing 28 endpoints as organ-effect-combinations. Toxicological and modelling experts did jointly the curation and selection of endpoints as an iterative proces…
Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties.
Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of alternative methods. Frameworks, such as the Read-across Assessment Framework or the Adverse Outcome Pathway Knowledge Base, support the development of these methods. The aim of the project presented in this publication was to develop substance categories for a read-across with complex endpoints of toxicity based on existing databases. The basic conceptual approach was to combine str…