0000000000388770

AUTHOR

Yoann Barnouin

showing 3 related works from this author

Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults

2019

© 2018 Elsevier B.V. With increasing life expectancy, age-associated cognitive impairment is an escalating problem worldwide. Inflammation is one of the features that characterises cognitive decline and can stimulate neurodegeneration. Interleukin 6 (IL-6) is a cytokine frequently associated with a pro-inflammatory phenotype and increased levels have been associated with the pathogenesis of dementia. The rs1800796 polymorphism in the promoter region of IL-6 gene was previously shown to influence IL-6 expression and therefore we hypothesised this gene polymorphism would be associated with IL-6 plasma levels and cognitive performance of older adults. The present study investigated the associa…

0301 basic medicinekognitioAgingPhysiologyinterleukin 6ta311103 medical and health sciencesCognitive aging0302 clinical medicineSDG 3 - Good Health and Well-beingGeneticsmedicineDementiaEffects of sleep deprivation on cognitive performanceCognitive declineEpisodic memoryGenetics (clinical)InflammationIL-6tulehdusWorking memorybusiness.industryCambridge Neuropsychological Test Automated BatterysytokiinitCognitionta3142medicine.diseasers1800796030104 developmental biologyikääntyminen030220 oncology & carcinogenesis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingGene polymorphismgeneettiset tekijätbusinessdementia
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Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance

2017

International audience; Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorph…

0301 basic medicinegamma interferon inducible protein 10genomic DNAAlzheimerin tautiEpigenesis GeneticCohort StudiesCXCL10 geneCognitionsingle nucleotide polymorphismcognitive defectCognitive declineAged 80 and overCerebral Cortexeducation.field_of_studyprefrontal cortexDNA methylationGeneral NeuroscienceadultNeurodegenerationneurodegenerationta3141U937 CellsMethylationta3142Alzheimer's diseasecohort analysisDNA-metylaatioagedfemalepriority journalepigenetiikkaDNA methylationAlzheimer's diseaseAlzheimer diseasetranscription regulationAlzheimer’s diseasekognitiiviset taidotmedicine.medical_specialty[SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]in vitro studyAdolescentheredityPopulationBiologyArticleworking memoryYoung Adult03 medical and health sciencesCognitive agingpromoter regionmaleMemoryInternal medicineJournal Articlemedicine[SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]HumansCXCL10controlled studyEpigeneticshumanbrain levelNeurodegenerationeducationepigeneticscognitive aginghuman cellagingdisease associationmedicine.diseasemajor clinical studyInflammagingChemokine CXCL10gamma interferon inducible protein 10; genomic DNA adult; age; aged; aging; Alzheimer disease; Article; brain level; cognitive defect; cohort analysis; controlled study; CpG island; CXCL10 gene; disease association; DNA methylation; epigenetics; female; heredity; human; human cell; in vitro study; inflammation; major clinical study; male; prefrontal cortex; priority journal; promoter region; single nucleotide polymorphism; transcription regulation; working memory; Alzheimer's disease; Cognitive aging; DNA methylation; Epigenetics; Inflammaging; Neurodegeneration030104 developmental biologyEndocrinologyikääntyminenageinflammationNerve DegenerationCpG islandinflammagingNeurology (clinical)Geriatrics and GerontologyHeLa CellsDevelopmental BiologyNeurobiology of Aging
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Plantarflexor Muscle-Tendon Properties are Associated With Mobility in Healthy Older Adults

2015

BACKGROUND: Muscle mass, strength, and power are known determinants of mobility in older adults but there is limited knowledge on the influence of muscle architecture or tendon properties on mobility. The purpose of this study was to examine the relationship between mobility and plantarflexor muscle-tendon properties in healthy older adults.METHODS: A total of 52 subjects (age 70-81 years) were measured for 6-minute walk test (6MWT), timed "up and go"-test (TUG), isometric plantarflexion strength, Achilles tendon stiffness, triceps surae muscle architecture, lower extremity lean mass, isometric leg extension strength, and leg extension power. Partial correlations and multivariate regression…

MaleAgingTendon stiffnesstendonmuscleIsometric exerciseWalkingPhysical performanceTendonsTriceps surae muscleMedicineta315Gait BiomechanicsAchilles tendonta3141SkeletalTendonmedicine.anatomical_structureMuscleFemalemedicine.medical_specialtyGastrocnemius muscleSkeletal/physiologycross-sectional studyMuscle architectureHumanshumanMuscle Strengthskeletal muscleMuscle SkeletalAgedbusiness.industrytendon stiffnessaged; aging; cross-sectional study; female; human; male; muscle strength; physiology; skeletal muscle; tendon; walking Aged; Aging; Cross-Sectional Studies; Female; Humans; Male; Muscle Strength; Muscle Skeletal; Tendons; Walking; Gait Biomechanics; Muscle; Muscle architecture; Physical performance; Tendon stiffnessphysical performancegait biomechanicsAging/physiologybody regionsMuscle Skeletal/physiologyCross-Sectional Studiesmuscle architecturephysiologyPhysical therapyLean body massFascicle lengthGeriatrics and GerontologybusinessMuscle architecturehuman activitiesTendons/physiologyJournals of Gerontology. Series A: Biological Sciences & Medical Sciences
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