Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes.

BACKGROUND Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes mellitus associated with high morbidity and mortality. Major risk factors for DPN include metabolic changes, duration of diabetes, nerve ischaemia and derangements in regeneration and nerve repair programmes. Chemokines have been previously implicated in the pathogenesis of various neuropathies and neuropathic pain processes. The aim of this pilot study was to evaluate the association between the plasma levels of chemokines (CXCL9, CXCL10 and CXCL11) in the presence of DPN in a cohort of type 2 diabetes (T2D) patients. MATERIALS AND METHODS We studied 73 patients with T2D: 36 with DPN and 37 without DPN. D…

Factores asociados con el ingreso hospitalario de pacientes diabéticos con ulceración en el pie

Fundamento Identificar y analizar los factores asociados con el ingreso hospitalario en diabeticos con ulceras en los pies, con el fin de identificar y tratar los pacientes de alto riesgo y evitar su ingreso hospitalario, que es la mayor fuente de gasto sanitario debido al pie diabetico. Sujetos y Metodo Hemos estudiado a 108 diabeticos (59 varones, edad media [DE] 68 [11] anos, 100 con diabetes tipo 2, con 16,4 [10,3] anos de evolucion) que acudieron a la unidad del pie diabetico desde enero 1996 hasta septiembre de 1997 con ulceras en los pies. En la primera visita se recogieron parametros clinicos y bioquimicos de riesgo en un protocolo clinico. Los sujetos fueron seguidos una media de 2…

Waist to hip ratio as a marker of insulin resistance in healthy subjects

Altered Semmes–Weinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects

Abstract Background Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabetic polyneuropathy and diabetic foot. In this study, we analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients. Methods Seventy T2DM patients were studied and 34 showed altered SWM results. The clinical and biochemical parameters were determined using standardized methods. Levels of oxidized glutathione (GSSG) and malondialdehyde (MDA) were measured in circulating mononuclear cells using high-performance liquid chro…