0000000000391704

AUTHOR

Jan-paul Zock

showing 3 related works from this author

Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

2015

Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes. © 2015 Cancer Research UK. All rights reserved.

OncologyMaleendocrine systemCancer Researchmedicine.medical_specialtyanimal structuresLymphomaEpidemiologyJob-exposure matrixchemicalsEndocrine Disruptors03 medical and health sciences0302 clinical medicineSex FactorsSex factorsRisk FactorsInternal medicinehemic and lymphatic diseasesOccupational ExposuremedicineOccupational exposure - endocrine disrupting chemicals (EDCs) - lymphoma riskEndocrine systemHumansurogenital systembusiness.industryIncidence (epidemiology)IncidenceCase-control studynutritional and metabolic diseasespesticidesmedicine.disease030210 environmental & occupational health3. Good healthLymphomaEuropeOccupational DiseasessolventsOncologyMulticenter study030220 oncology & carcinogenesisCase-Control StudiesImmunologyleukaemiaalkylphenolsFemaleOccupational exposurebusinesshormones hormone substitutes and hormone antagonists
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Occupational exposure to immunologically active agents and risk for lymphoma: The European Epilymph case-control study

2013

Objectives: Allergies and asthma may be protective for the development of lymphoma. We evaluated whether occupational allergens that provoke immune reactivity and asthma through an IgE-mediated pathway are protective for lymphoma. Methods: The Epilymph study includes histologically or cytologically confirmed Hodgkin, B-cell, and T-cell lymphoma cases from six European countries (Spain, France, Germany, Italy, Ireland, and Czech Republic) recruited in 1998-2004. Controls were frequency matched to cases by age, gender, and study centre. Lifetime occupational exposure to seven high molecular weight (HMW) agents was evaluated through an asthma-specific job-exposure matrix. 2205 lymphoma cases a…

AdultMaleRiskCancer Researchmedicine.medical_specialtyAllergyLymphoma B-CellEpidemiologyHigh molecular weight exposuresLymphoma T-CellImmunoglobulin ELogistic regressionYoung Adultimmune system diseasesInternal medicinehemic and lymphatic diseasesEpidemiologyHypersensitivitymedicineHumansAsthma OccupationalYoung adultAgedAsthmabiologybusiness.industryCase-control studyAllergensImmunoglobulin EMiddle AgedOccupational exposuremedicine.diseaseHodgkin DiseaseLymphomaEuropeMolecular WeightOccupational DiseasesLogistic ModelsOncologyCase-Control StudiesImmunologybiology.proteinFemalebusinessCase–control
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Prenatal and postnatal residential usage of insecticides in a multicenter birth cohort in Spain

2013

Abstract: This study aimed to describe the residential use of insecticides in a birth cohort in Spain. Study subjects were 2 456 women enrolled into the INMA (Environment and Childhood) birth cohort followed prospectively during pregnancy and in the early postnatal period. The women were recruited at the beginning of their pregnancy between 2003 and 2008 in four regions of Spain. Socio-demographic, environmental and lifestyle information was obtained at two interviews during pregnancy, one at the first (mean:13.8 +/- 2.6 weeks of gestation) and the other at the third trimester (mean: 33.3 +/- 23 weeks of gestation). Information about prenatal use of indoor and outdoor insecticides (type, ti…

AdultPediatricsmedicine.medical_specialtyInsecticidesEnvironmental EngineeringSelf-reportedPregnancyEnvironmental healthmedicineEnvironmental ChemistryHumansLongitudinal StudiesWaste Management and DisposalLife StyleBiologyApplication methodsInsecticidePregnancybusiness.industryEnvironmental exposureEnvironmental Exposuremedicine.diseaseResidentialPollutionChildhoodPesticideChemistryLifestyle factorsSocioeconomic FactorsMaternal ExposureSpainGestationRegression AnalysisResidenceFemaleBirth cohortbusinessBedroom
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