0000000000391977
AUTHOR
Eeva-kaarina Pellinen
Auditory cortical and hippocampal local-field potentials to frequency deviant tones in urethane-anesthetized rats: An unexpected role of the sound frequencies themselves
The human brain can automatically detect auditory changes, as indexed by the mismatch negativity of event-related potentials. The mechanisms that underlie this response are poorly understood. We recorded primary auditory cortical and hippocampal (dentate gyrus, CA1) local-field potentials to serial tones in urethane-anesthetized rats. In an oddball condition, a rare (deviant) tone (p = 0.11) randomly replaced a repeated (standard) tone. The deviant tone was either lower (2200, 2700, 3200, 3700 Hz) or higher (4300, 4800, 5300, 5800 Hz) in frequency than the standard tone (4000 Hz). In an equiprobability control condition, all nine tones were presented at random (p = 0.11). Differential respo…
Mismatch responses to sound duration changes in the rat auditory cortex and hippocampus
TIIVISTELMÄ Ääniympäristön muutosten havaitseminen on tärkeää selviytymiselle. Aivojen herätevasteista niin sanotun poikkeavuusnegatiivisuusvasteen (mismatch negativity, MMN) on ajateltu heijastavan tällaisten muutosten tarkkaavuudesta riippumatonta havaitsemista. Tutkimustilanteissa poikkeavuusnegatiivisuusvaste voidaan synnyttää sirottelemalla toistuvien ‟standardiäänten‟ joukkoon joltakin ärsykeominaisuudeltaan havaittavissa määrin poikkeavia harvinaisia ‟devianttiääniä‟ (niin sanottu oddball-asetelma). Poikkeavuusnegatiivisuusvasteen tuottamista on yleisesti pidetty aivokuoren toimintona. Hippokampuksen sen sijaan on ajateltu vaikuttavan huomattavampien muutosten havaitsemiseen ja huomi…
Auditory cortical and hippocampal local-field potentials to frequency deviant tones in urethane-anesthetized rats: An unexpected role of the sound frequencies themselves
Abstract The human brain can automatically detect auditory changes, as indexed by the mismatch negativity of event-related potentials. The mechanisms that underlie this response are poorly understood. We recorded primary auditory cortical and hippocampal (dentate gyrus, CA1) local-field potentials to serial tones in urethane-anesthetized rats. In an oddball condition, a rare (deviant) tone ( p = 0.11) randomly replaced a repeated (standard) tone. The deviant tone was either lower (2200, 2700, 3200, 3700 Hz) or higher (4300, 4800, 5300, 5800 Hz) in frequency than the standard tone (4000 Hz). In an equiprobability control condition, all nine tones were presented at random ( p = 0.11). Diffe…