0000000000392422
AUTHOR
G Spitaleri
The Cozzo Disi mine (Casteltermini, Sicily, Italy) a multi-disciplinary approach to record, study, preserve and develop the mining heritage in Sicily
Cozzo Disi was one of the main sulphur mines in Italy, but after the closure and more than 10 years of desertion, urgent works are now necessary to save it from vandalism and flooding. This big mine contains geological and mineralogical peculiarities, so uncommon to be sometimes unique: this is the case of the “Grandi Garbere” at 3rd level, majestic karst cavities, containing magnificent selenite crystals documented by old miners. The possibility to have a “Sicilian Naica” attracted a multi-disciplinary underground task-force, now exploring the mine underground, in order to inspect old works and their good-safety conditions, and to achieve the rooms/caves of “Grandi Garbere”. This extraordi…
Inside The Glaciers Project: Laser Scanning Of The Grotta Del Gelo (Mount Etna, Italy)
As part of activities of the “Inside the Glaciers” project, managed by an Italian team of speleologists and geologists with the purpose of studying several ice-caves in Europe and South America, a research campaign was recently carried out in Mount Etna (Sicily, Italy). This volcano is the highest active in Europe and hosts more than 200 caves including Grotta del Gelo (Ice Cave) which is located on the Northern flank of Mount Etna at an altitude of about 2040 m a.s.l. This cave was formed during the Etna’s long and most destructive eruption dated from 1614 to 1624 and is one of the most famous because it hosts a small glacier, maybe the southernmost of the Northern hemisphere. Aim of this …
Empagliflozin in heart failure with preserved ejection fraction: decoding its molecular mechanism of action using artificial intelligence
Abstract Rationale The use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) to treat heart failure with preserved ejection fraction (HFpEF) is under investigation in ongoing clinical trials, but the exact mechanism of action is unclear. Here we aimed to use artificial intelligence (AI) to characterize the mechanism of action of empagliflozin in HFpEF at the molecular level. Methods We retrieved information regarding HFpEF pathophysiological motifs and differentially expressed genes/proteins, together with empagliflozin target information and bioflags, from specialized publicly available databases. Artificial neural networks and deep learning AI were used to model the molecular effec…
Head-to-head comparison of contemporary heart failure risk scores.
Altres ajuts: acords transformatius de la UAB Aims: Several heart failure (HF) web-based risk scores are currently used in clinical practice. Currently, we lack head-to-head comparison of the accuracy of risk scores. This study aimed to assess correlation and mortality prediction performance of Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC-HF) risk score, which includes clinical variables + medications; Seattle Heart Failure Model (SHFM), which includes clinical variables + treatments + analytes; PARADIGM Risk of Events and Death in the Contemporary Treatment of Heart Failure (PREDICT-HF) and Barcelona Bio-Heart Failure (BCN-Bio-HF) risk calculator, which also include biomarke…