0000000000392490
AUTHOR
Vd Longo
A radical signal activates the epigenetic regulation of longevity
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.
The yeast chronological lifespan to study aging and disease
The yeast chronological lifespan to study aging and disease. In S.N. Witt (a cura di), yeast as a model for human disease.