0000000000394205

AUTHOR

Antonella Conte

showing 8 related works from this author

Towards a validated definition of the clinical transition to secondary progressive multiple sclerosis: A study from the Italian MS Register.

2022

Background: Definitions for reliable identification of transition from relapsing-remitting multiple sclerosis (MS) to secondary progressive (SP)MS in clinical cohorts are not available. Objectives: To compare diagnostic performances of two different data-driven SPMS definitions. Methods: Data-driven SPMS definitions based on a version of Lorscheider’s algorithm (DDA) and on the EXPAND trial inclusion criteria were compared, using the neurologist’s definition (ND) as gold standard, in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Akaike information criterion (AIC) and area under the curve (AUC). Results: A cohort of 10,240 MS patients wi…

Multiple SclerosisMultiple Sclerosis Chronic ProgressiveMultiple sclerosisMultiple Sclerosis Relapsing-RemittingNeurologybig dataArea Under Curvedata-driven algorithmdisease registrysecondary progressiveHumansSettore MED/26 - NeurologiaNeurology (clinical)prognosisMultiple sclerosis (Houndmills, Basingstoke, England)
researchProduct

Bacterial community structure along the subtidal sandy sediment belt of a high Arctic fjord (Kongsfjorden, Svalbard Islands)

2018

Open fjords are subject to contrasting environmental conditions, owing to meltwater glacial inputs, terrestrial runoff, and marine water mass exchanges, which are exacerbated by anthropogenic and climate perturbations. Following a slope-dependent water circulation, the subtidal sandy sediment belt regulates the convergent transport of nutrients downward the fjord depths, and the effective entrapment of suspended particles and microorganisms. In this study, we aimed at testing how glacial and seawater inputs may influence the bacterial community structure of subtidal sand deposits in the Kongsfjorden. Through total and viable cell counting and an amplicon sequencing approach, we found releva…

0301 basic medicineWater massEnvironmental EngineeringFjordmicrobial community compositioncoastal sands03 medical and health sciencesEnvironmental Chemistryta219Glacial periodMeltwaterglacial inputsWaste Management and Disposalgeographygeography.geographical_feature_categoryCommunityion PGM sequencingCommunity structureSedimentGlacierPollution030104 developmental biologyOceanographyCoastal sands Glacial inputs Ion PGM sequencing Microbial community composition Prokaryotic abundance Environmental Engineering Environmental Chemistry Waste Management and Disposal PollutionGeologyprokaryotic abundanceScience of the Total Environment
researchProduct

Prokaryotic assemblages within permafrost active layer at Edmonson Point (Northern Victoria Land, Antarctica)

2018

This study was aimed at gaining insights on the prokaryotic community (in terms of both taxonomic composition and activities) inhabiting the active layer at Edmonson Point, an ice-free area on the eastern slope at the foot of Mount Melbourne (Northern Victoria Land, Antarctica). Samples were collected during the thawing period, when microbial physiological activities are restored to utilize previously frozen organic substrates. Despite the very small cell sizes (600 daltons) substrates, as indicated also by the obtained rates of enzymatic hydrolytic activities over proteolytic, glycolitic and phosphoric compounds. Taxonomical composition showed that Proteobacteria, Actinobacteria and Firmic…

0301 basic medicinemetabolic activitiesFirmicutesta1172seasonally thawed active layerSoil ScienceikiroutaAntarctica; Metabolic activities; Prokaryotic community; Seasonally thawed active layer; Microbiology; Soil SciencePermafrostMicrobiologyActinobacteria03 medical and health sciencesAbundance (ecology)Organic mattermikrobitaineenvaihduntaNitrogen cycleAntarctica Metabolic activities Prokaryotic community Seasonally thawed active layer Microbiology Soil Sciencechemistry.chemical_classificationbiologyEcologyta1183prokaryotic communitybiology.organism_classificationmikrobisto030104 developmental biologychemistryHabitatEnvironmental scienceAntarcticaantarktinen alueProteobacteria
researchProduct

Hematopoietic Stem Cell Transplantation in People With Active Secondary Progressive Multiple Sclerosis

2023

Background and ObjectivesUncontrolled evidence suggests that autologous hematopoietic stem cell transplantation (AHSCT) can be effective in people with active secondary progressive multiple sclerosis (SPMS). In this study, we compared the effect of AHSCT with that of other anti-inflammatory disease-modifying therapies (DMTs) on long-term disability worsening in active SPMS.MethodsWe collected data from the Italian Bone Marrow Transplantation Study Group and the Italian Multiple Sclerosis Register. Patients were considered eligible if treatment had been started after the diagnosis of SPMS. Disability worsening was assessed by the cumulative proportion of patients with a 6-month confirmed dis…

Hematopoietic Stem Cell TransplantationActive Secondary Progressive Multiple SclerosisNeurology (clinical)Research Article
researchProduct

Long-term disability trajectories in relapsing multiple sclerosis patients treated with early intensive or escalation treatment strategies

2021

Background and aims: No consensus exists on how aggressively to treat relapsing–remitting multiple sclerosis (RRMS) nor on the timing of the treatment. The objective of this study was to evaluate disability trajectories in RRMS patients treated with an early intensive treatment (EIT) or with a moderate-efficacy treatment followed by escalation to higher-efficacy disease modifying therapy (ESC). Methods: RRMS patients with ⩾5-year follow-up and ⩾3 visits after disease modifying therapy (DMT) start were selected from the Italian MS Registry. EIT group included patients who received as first DMT fingolimod, natalizumab, mitoxantrone, alemtuzumab, ocrelizumab, cladribine. ESC group patients rec…

Pediatricsmedicine.medical_specialtybig data; disability trajectories; disease registry; multiple sclerosis.multiple sclerosis03 medical and health sciences0302 clinical medicineDisease registrybig dataMedicine030212 general & internal medicineRC346-429Original Researchbig data; disability trajectories; disease registry; multiple sclerosisPharmacologybusiness.industryMultiple sclerosisLong term disabilitymedicine.diseaseNeurologydisease registryTreatment strategySettore MED/26 - Neurologiadisability trajectoriesNeurology. Diseases of the nervous systemNeurology (clinical)business030217 neurology & neurosurgeryTherapeutic Advances in Neurological Disorders
researchProduct

Enrichment, isolation and biodegradation potential of psychrotolerant polychlorinated-biphenyl degrading bacteria from the Kongsfjorden (Svalbard Isl…

2016

Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), have been detected in abiotic Arctic matrices: surface sediments and seawater from coastal areas in the Kongsfjorden were collected and analyzed. Levels of PCBs varied depending on the sampling site. Total PCB concentrations were between 11.63 (site C2W) and 27.69 pg l-1 (site AW). These levels were comparable to those reported previously in lake sediments from the northern Svalbard. The occurrence and biodegradation potential of cold-adapted PCB-oxidizing bacteria in seawater and sediment along the fjord was also evaluated. After enrichment with biphenyl, 246 isolates were obtained with 45 of them that were abl…

0301 basic medicineCold-adapted bacteria; Polychlorobiphenyls; Contamination level; Arctic fjord; BiodegradationGeologic Sediments010501 environmental sciencesarctic fjordsOceanography01 natural sciencesSvalbardchemistry.chemical_compoundPolychlorobiphenylsArctic fjordBiphenylgeography.geographical_feature_categorybiologyArctic RegionsEcologyPolychlorinated BiphenylsPollutionAerobiosisBacteria AerobicCold TemperatureBiodegradation EnvironmentalEnvironmental chemistryArctic fjord; Biodegradation; Cold-adapted bacteria; Contamination level; Polychlorobiphenyls; Oceanography; Aquatic Science; PollutionBiodegradationEstuariesWater MicrobiologyDevosiaAroclorsta1172GelidibacterCold-adapted bacteria Polychlorobiphenyls Contamination level Arctic fjord BiodegradationFjordAquatic Science03 medical and health sciencesCold adapted bacteriaSeawaterta2190105 earth and related environmental sciencesgeographyCold-adapted bacteriaPolychlorinated biphenylBiodegradationbiology.organism_classificationContamination level030104 developmental biologychemistryAlgoriphagusSeawaterWater Pollutants Chemical
researchProduct

Bacterial Diversity in a Dynamic and Extreme Sub-Arctic Watercourse (Pasvik River, Norwegian Arctic)

2020

Microbial communities promptly respond to the environmental perturbations, especially in the Arctic and sub-Arctic systems that are highly impacted by climate change, and fluctuations in the diversity level of microbial assemblages could give insights on their expected response. 16S rRNA gene amplicon sequencing was applied to describe the bacterial community composition in water and sediment through the sub-Arctic Pasvik River. Our results showed that river water and sediment harbored distinct communities in terms of diversity and composition at genus level. The distribution of the bacterial communities was mainly affected by both salinity and temperature in sediment samples, and by oxygen…

lcsh:Hydraulic engineeringGeography Planning and DevelopmentClimate changesedimentitAquatic ScienceBiochemistryAlgal bloombakteerit03 medical and health scienceslcsh:Water supply for domestic and industrial purposeslcsh:TC1-978Glacial period030304 developmental biologyWater Science and TechnologyPhylotypearktinen aluelcsh:TD201-5000303 health sciences030306 microbiologyEcologyvesiekosysteemitbacterial diversityriver sediment and waterSedimentmikrobiekologiaSalinitymikrobistoTaxonvirtavedetNGSsub-Arctic systemEnvironmental scienceSurface runoffjoetWater
researchProduct

Transition to secondary progression in relapsing-onset multiple sclerosis: Definitions and risk factors

2021

Background: No uniform criteria for a sensitive identification of the transition from relapsing–remitting multiple sclerosis (MS) to secondary-progressive multiple sclerosis (SPMS) are available. Objective: To compare risk factors of SPMS using two definitions: one based on the neurologist judgment (ND) and an objective data-driven algorithm (DDA). Methods: Relapsing-onset MS patients ( n = 19,318) were extracted from the Italian MS Registry. Risk factors for SPMS and for reaching irreversible Expanded Disability Status Scale (EDSS) 6.0, after SP transition, were estimated using multivariable Cox regression models. Results: SPMS identified by the DDA ( n = 2343, 12.1%) were older, more disa…

Oncologymedicine.medical_specialtyRelapsing-RemittingMultiple sclerosis03 medical and health sciencesMultiple Sclerosis Relapsing-Remitting0302 clinical medicineDisease registryRecurrenceRisk Factorsbig dataInternal medicinemedicineHumansdata-driven algorithmMultiple sclerosi030212 general & internal medicinebig data; data-driven algorithm; disease registry; Multiple sclerosis; prognosis; secondary progressive; Disease Progression; Humans; Recurrence; Risk Factors; Multiple Sclerosis; Multiple Sclerosis Chronic Progressive; Multiple Sclerosis Relapsing-RemittingSecondary progressiveTransition (genetics)business.industryMultiple sclerosisMultiple Sclerosis Chronic Progressivemedicine.diseaseChronic ProgressiveNeurologybig data; data-driven algorithm; disease registry; Multiple sclerosis; prognosis; secondary progressiveDisease Progressiondisease registrysecondary progressiveSettore MED/26 - NeurologiaNeurology (clinical)prognosisbusinessprognosi030217 neurology & neurosurgery
researchProduct