0000000000394590

AUTHOR

Susanne Hemmer

showing 2 related works from this author

A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q

2001

Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of approximately 1% in all human populations. In order to identify chromosomal regions containing genes that play a role in determining susceptibility to this psychiatric condition, we have conducted a complete genome screen with 382 markers (average marker spacing of 9.3 cM) in a sample of 75 BPAD families which were recruited through an explicit ascertainment scheme. Pedigrees were of German, Israeli and Italian origin, respectively. Parametric and non-parametric linkage analysis was performed. The highe…

MaleBipolar DisorderGenotypePopulationPedigree chartLocus (genetics)BiologyNuclear FamilyVeinsGenomic ImprintingGenetic linkageLeukocytesGeneticsmedicineHumansGenetic Predisposition to DiseaseGenetic TestingBipolar disordereducationMolecular BiologyGenetics (clinical)Chromosomes Human Pair 14Geneticseducation.field_of_studyAutosomeChromosome MappingDNAGeneral Medicinemedicine.diseasePedigreePhenotypeChromosomes Human Pair 2FemaleLod Scoremedicine.symptomGenomic imprintingManiaChromosomes Human Pair 16Chromosomes Human Pair 8Microsatellite RepeatsHuman Molecular Genetics
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Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families.

1999

Previously reported linkage of bipolar affective disorder to DNA markers on chromosome 18 was reexamined in a large sample of German bipolar families. Twenty-three short tandem repeat markers were investigated in 57 families containing 103 individuals with bipolar I disorder (BPI), 26 with bipolar II disorder (BPII), nine with schizoaffective disorder of the bipolar type (SA/BP), and 38 individuals with recurrent unipolar depression (UPR). Evidence for linkage was tested with parametric and non-parametric methods under two definitions of the affected phenotype. Analysis of all 57 families revealed no robust evidence for linkage. Following previous reports we performed separate analyses afte…

Genetic MarkersMaleBipolar I disorderBipolar DisorderGenetic LinkageSchizoaffective disorderGenes RecessiveGenetic determinismNuclear FamilyCellular and Molecular NeuroscienceBipolar II disorderGenomic ImprintingChromosome 18GermanymedicineHumansFamilyBipolar disorderMolecular BiologyGenes DominantLinkage (software)GeneticsRecombination GeneticSex CharacteristicsModels GeneticChromosome Mappingmedicine.diseasePsychiatry and Mental healthChromosomal regionFemaleLod ScorePsychologyChromosomes Human Pair 18Molecular psychiatry
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