0000000000394763
AUTHOR
C. Osmond
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity
The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses i…
CHILDHOOD ADVERSITIES AND HOME ATMOSPHERE AS DETERMINANTS OF DISABILITY AND UNEMPLOYMENT PENSION
Childhood adversities have been linked with adverse life events, but less is known about the long-term effects of childhood home atmosphere in terms of work career. We investigated whether childhood adversities and home atmosphere were associated with disability or unemployment pension. In the Helsinki Birth Cohort Study (born 1934–44), 2001 cohort members had data available on 9 childhood home atmosphere items e.g. whether it was supportive or warm (sum score 0–36, higher score indicating more favorable atmosphere), and 9 childhood adversities e.g. unemployment, parent’s long-term illness or divorce (sum score 0–9, coded into no; one; and two or more) assessed in 2001–04. Of those, 1528 ha…