0000000000398138

AUTHOR

Francisco Cernicharo-toledo

showing 2 related works from this author

Enantioselective Friedel-Crafts reaction of hydroxyarenes with nitroenynes to access chiral heterocycles via sequential catalysis

2021

Naphthols, hydroxyindoles and an activated phenol are reacted with differently substituted (E)-nitrobut-1-en-3-ynes using the commercially available Rawal's chiral squaramide. The corresponding β-nitroalkynes were obtained with good yields and excellent enantioselectivities. Moreover, dihydronaphthofurans can be accessed via silver catalysed cyclization in a tandem one-pot procedure, with high preservation of the optical purity.

TandemOrganic ChemistryEnantioselective synthesisSquaramideBiochemistryCatalysischemistry.chemical_compoundchemistryCatàlisiPhenolOrganic chemistryPhysical and Theoretical ChemistryEnantiomeric excessFriedel–Crafts reactionQuímica orgànica
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Nitroenynes as Electrophiles in Organocatalysis and their Application in the Synthesis of Chiral Heterocycles

2021

Nitroenynes are an interesting electrophile in asymmetric organocatalysis, due to the versatility of the functional groups present in its structure. This review covers the organocatalytic examples using this electrophile and its application for the synthesis of chiral heterocycles.

Compostos de nitrogenCatàlisiChemistryOrganocatalysisOrganic ChemistryElectrophilePhysical and Theoretical ChemistryQuímica orgànicaCombinatorial chemistryEuropean Journal of Organic Chemistry
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