0000000000398544

AUTHOR

Chris J. J. Mulder

showing 4 related works from this author

The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update

2017

Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion.

0301 basic medicinemedicine.medical_specialtySettore MED/09 - Medicina InternaGlutensamylase-trypsin inhibitors (ATIs)Gluten sensitivitylcsh:TX341-641Non-Celiac Gluten SensitivityReviewWheat HypersensitivityGastroenterologyIrritable Bowel Syndrome03 medical and health sciencesDiet Gluten-Free0302 clinical medicineMalabsorption Syndromesgluten-free dietMedizinische FakultätInternal medicineMedicineHumansddc:610Irritable bowel syndromeImmune mechanismsRandomized Controlled Trials as Topicgluten-related disorder030109 nutrition & dieteticsNutrition and Dieteticsbusiness.industrygluten sensitivitynutritional and metabolic diseasesGluten-related disordersWheat-Sensitive Irritable Bowel Syndromemedicine.diseaseMalabsorption Syndromedigestive system diseasesNon-Celiac Gluten Sensitivity; Wheat-Sensitive Irritable Bowel SyndromeReview articlewheat allergy030211 gastroenterology & hepatologybusinessNon-celiac gluten sensitivitygluten-related disorderslcsh:Nutrition. Foods and food supplyWheat allergyGlutenceliac diseaseFood ScienceHuman
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Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity : A Multicentre Study

2022

Background: Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) are poorly defined. \ud \ud \ud \ud Objectives: To evaluate the structural and inflammatory features of NCGS compared to controls and coeliac disease (CeD) with milder enteropathy (Marsh I-II). \ud \ud \ud \ud Methods: Well-oriented biopsies of 262 control cases with normal gastroscopy and histologic findings, 261 CeD, and 175 NCGS biopsies from 9 contributing countries were examined. Villus height (VH, in μm), crypt depth (CrD, in μm), villus-to-crypt ratios (VCR), IELs (intraepithelial lymphocytes/100 enterocytes), and other relevant histological, serologic, and…

Settore MED/12 - GastroenterologiaNutrition and DieteticsSettore MED/09 - Medicina InternaGlutensDuodenumnon-coeliac gluten sensitivityBiopsySettore MED/08 - Anatomia Patologica3121 Internal medicinedigestive systemhistologynormal mucosaCeliac DiseaseDiet Gluten-FreeHumansIntestinal Mucosanon-coeliac gluten sensitivity; histology; normal mucosa; coeliac diseasecoeliac disease; histology; non-coeliac gluten sensitivity; normal mucosacoeliac diseaseFood Science
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Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria

2015

Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease or wheat allergy. Given the lack of a NCGS biomarker, there is the need for standardizing the procedure leading to the diagnosis confirmation. In this paper we report experts' recommendations on how the diagnostic protocol should be performed for the confirmation of NCGS. A full diagnostic procedure should assess the clinical response to the gluten-free diet (GFD) and measure the effect of a gluten challenge after a period of treatment with the GFD. The clinical evaluation i…

Diagnosis; Non-Celiac Gluten SensitivityPediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaGlutensdiagnosislcsh:TX341-641DiseasePlaceboArticleDiet Gluten-FreeDouble-Blind MethodRating scaleSurveys and QuestionnairesHumansMedicineIntestinal MucosaIrritable bowel syndromedouble-blind placebo-controlled challengechemistry.chemical_classificationirritable bowel syndromeCross-Over StudiesNutrition and Dieteticsbusiness.industrynon-celiac gluten sensitivitygastrointestinal symptom rating scalenutritional and metabolic diseasesmedicine.diseaseGlutenCrossover studySurgerychemistryImmunoglobulin GBiomarker (medicine)businesslcsh:Nutrition. Foods and food supplyBiomarkersFood HypersensitivityWheat allergyFood ScienceDiagnosiNutrients
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ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation

2017

ObjectivesCounting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive ‘normal’ IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, based on IEL counts on >400 mucosal biopsy specimens.DesignThe study was designed at the International Meeting on Digestive Pathology, Bucharest 2015. Investigators from 19 centres, eight countries of three continents, recruited 198 patients with Marsh III histology and 203 controls and used one agreed protocol to count IEL/100 ent…

MalePathologySettore MED/09 - Medicina Interna2312ROC-curve analysiBiopsyCoeliac diseaseSerology0302 clinical medicineintraepithelial lymphocytesDiagnosis80 and overROC-curve analysis; coeliac disease; intraepithelial lymphocytes1506LymphocytesIntestinal MucosaChild1507medicine.diagnostic_testArea under the curveGastroenterologyhemic and immune systemsMiddle AgedPrognosis030220 oncology & carcinogenesis030211 gastroenterology & hepatologyFemalemedicine.symptomtissuesAdultmedicine.medical_specialtyAdolescentchemical and pharmacologic phenomenaBiologydigestive systemLesion03 medical and health sciencesBiopsymedicineHumansLymphocyte CountPreschoolAgedReceiver operating characteristicInfantHistologymedicine.diseaseNewbornROC-curve analysis; coeliac disease; intraepithelial lymphocytes; Adolescent; Adult; Aged; Aged 80 and over; Biopsy; Case-Control Studies; Celiac Disease; Child; Child Preschool; Diagnosis Differential; Female; Humans; Infant; Infant Newborn; Intestinal Mucosa; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Prognosis; ROC Curve; GastroenterologyCeliac DiseaseROC CurveCase-Control StudiesDifferentialIntraepithelial lymphocyteROC-curve analysiscoeliac disease
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