0000000000398635

AUTHOR

Christine Fischer

showing 5 related works from this author

6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease.

2005

Background & Aims: Azathioprine is the gold standard for immunosuppressive therapy in Crohn's disease (CD) and its molecular mechanism of action is caused by the metabolite 6-thioguanosine triphosphate (TGTP). In this study we assessed the impact of TGTP levels for monitoring of azathioprine therapy. Methods: A novel, highly sensitive assay was established to measure levels of TGTP and its precursors 6-thioguanosine monophosphates and 6-thioguanosine diphosphates (TGDP) in red blood cells from 50 CD patients. The results were correlated with clinical outcome. Results: TGTP levels could be quantified in 47 patients and a subgroup of these patients showed significantly high levels of TGDP. 6-…

Adultmedicine.medical_specialtyErythrocytesMetaboliteAzathioprineInflammatory bowel diseaseGastroenterologyGuanosine Diphosphatechemistry.chemical_compoundCrohn DiseaseInternal medicineAzathioprinemedicineHumansCrohn's diseaseHepatologyThiopurine methyltransferasebiologybusiness.industryGastroenterologyAzathioprine therapyAntibodies MonoclonalThionucleotidesmedicine.diseaseInfliximabGuanine NucleotidesInfliximabRed blood cellmedicine.anatomical_structurechemistryImmunologybiology.proteinbusinessBiomarkersImmunosuppressive Agentsmedicine.drugClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
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6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4

2008

Multiple drug resistance protein 4 (MRP4, ABCC4) belongs to the C subfamily of the ATP-binding cassette (ABC) transporter superfamily and participates in the transport of diverse antiviral and chemotherapeutic agents such as 6-mercaptopurine (6-MP) and 9-(2-phosphonyl methoxyethyl) adenine (PMEA). We have undertaken a comprehensive functional characterization of protein variants of MRP4 found in Caucasians and other ethnicities. A total of 11 MRP4 missense genetic variants (nonsynonymous SNPs), fused to green fluorescent protein (GFP), were examined in Xenopus laevis oocytes for their effect on expression, localization, and function of the transporter. Radiolabeled 6-MP and PMEA were chosen…

Recombinant Fusion ProteinsGreen Fluorescent ProteinsMutation MissenseOrganophosphonatesXenopusATP-binding cassette transporterABCC4BiologyGreen fluorescent proteinXenopus laevisGeneticsAnimalsHumansMissense mutationGenetics (clinical)DNA Primerschemistry.chemical_classificationBase SequenceMercaptopurineAdenineWild typebiology.organism_classificationMolecular biologyTransmembrane proteinAmino acidchemistryBiochemistryMutagenesis Site-Directedbiology.proteinMultidrug Resistance-Associated ProteinsHuman Mutation
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Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic t…

2015

Aims The impact of exercise training on the right heart and pulmonary circulation has not yet been invasively assessed in patients with pulmonary hypertension (PH) and right heart failure. This prospective randomized controlled study investigates the effects of exercise training on peak VO2/kg, haemodynamics, and further clinically relevant parameters in PH patients. Methods and results Eighty-seven patients with pulmonary arterial hypertension and inoperable chronic thrombo-embolic PH (54% female, 56 ± 15 years, 84% World Health Organization functional class III/IV, 53% combination therapy) on stable disease-targeted medication were randomly assigned to a control and training group. Medica…

Malemedicine.medical_specialtyCardiac outputHypertension PulmonaryVentricular Dysfunction RightCardiac indexHemodynamics610 Medicine & health030204 cardiovascular system & hematology2705 Cardiology and Cardiovascular Medicine03 medical and health sciences0302 clinical medicineOxygen ConsumptionHeart RateInternal medicineThromboembolismHeart rateNatriuretic Peptide BrainmedicineHumansProspective StudiesPulmonary Wedge PressureCardiac OutputPulmonary wedge pressureProspective cohort studyAnalysis of VarianceExercise Tolerancebusiness.industryMiddle Agedmedicine.diseasePulmonary hypertensionPeptide FragmentsSurgeryExercise Therapymedicine.anatomical_structureTreatment Outcome030228 respiratory systemChronic DiseaseVascular resistanceCardiologyExercise TestFemaleVascular Resistance10178 Clinic for PneumologyCardiology and Cardiovascular MedicinebusinessBiomarkersEuropean heart journal
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Exercise training improves peak oxygen consumption and hemodynamics in patients with pulmonary hypertension – A prospective, randomized, controlled t…

2016

Aims: This prospective randomized controlled study investigates the effects of exercise training on peak VO 2 /kg, hemodynamics and further clinically relevant parameters in pulmonary hypertension (PH) patients. Methods: Eighty-seven patients with pulmonary arterial hypertension and inoperable chronic thromboembolic PH (54% female, 56±15years, 84% WHO functional class III/IV, 53% combination therapy) on stable disease-targeted medication were randomly assigned to a control and training group. Medication remained unchanged during the study period. Non-invasive assessments and right heart catheterization at rest and during exercise were performed at baseline and after 15 weeks. Primary endpoi…

Right heart catheterizationmedicine.medical_specialtyVentricular functionCombination therapybusiness.industryHemodynamicsmedicine.diseasePulmonary hypertensionlaw.invention03 medical and health sciences0302 clinical medicine030228 respiratory systemRandomized controlled triallawInternal medicineClinical endpointPhysical therapyCardiologyMedicineIn patient030212 general & internal medicinebusiness1.2 Rehabilitation and Chronic Care
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<p>Chemotherapy of Locally Advanced or Metastatic Urothelial Cell Carcinoma: Monocentric Real-Life Data</p>

2020

Background/Aim Up to 30% of all patients will present with an advanced or a metastatic stage (mUCC) at the moment of the initial diagnosis of urothelial cell carcinoma of the bladder (UCC). We investigated the numbers, the efficacy and toxicity of different chemotherapies for mUCC in daily practice and "real-life" conditions and evaluated them substance-specifically. Patients and Methods All patients with a mUCC, who were treated between January 1, 2006 and October 31, 2016 at the Department of Urology and Pediatric Urology at University Hospital Marburg (Germany), were retrospectively analyzed. We set the focus on demographic and tumor-specific data as well as on effectiveness, therapy seq…

0301 basic medicineCisplatinOncologyChemotherapymedicine.medical_specialtyBladder cancerMetastatic Urothelial Carcinomabusiness.industrymedicine.medical_treatmentmedicine.diseaseGemcitabinePediatric urology03 medical and health sciences030104 developmental biology0302 clinical medicineOncologyUrothelial cell carcinoma030220 oncology & carcinogenesisInternal medicinemedicineStage (cooking)businessmedicine.drugCancer Management and Research
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