ADIPOSE TISSUE-TARGETED STEM CELL TRANSPLANTATION FOR INSULIN RESISTANCE-RELATED CNS DEFICITS
Compelling evidence indicates that Type 2 Diabetes (T2D) and Alzheimer’s Disease (AD) may possibly share a common pathological origin, but the underlying mechanisms remain poorly understood. T2D is a known risk factor for AD and insulin resistance (hallmark of T2D) has been extensively documented in AD patients. Notably, insulin is important for learning and memory due to its role in LTP and LTD modulation. Adipose tissue (AT) dysfunction is a risk factor for T2D, in fact elevated levels of free fatty acids are prodromal to insulin resistance and have been reported in AD brains, as well. In this study, I used a mouse model (AtENPP1Tg mouse) that recapitulates typical characteristics of huma…
Analisi di biomarcatori urinari e tissutali coinvolti nei meccanismi pro- o anti-fibrotici in pazienti con stenosi del giunto pielo-ureterale unilaterale congenita come ulteriore strumento nel management terapeutico.
Stenosi del giunto pielo-ureterale, biomarcatori urinari, fibrosi, funzione renale, matrice extracellulare.
The Immunomodulatory Features of Mesenchymal Stromal Cells Derived from Wharton’s Jelly, Amniotic Membrane, and Chorionic Villi In Vitro and In Vivo Data
This chapter focuses on the immunomodulatory properties of placental mesenchymal stromal cells (MSCs) derived from the amniotic membrane, umbilical cord, and chorionic villi. Within the amniotic membrane (AM), we discuss the immunomodulatory properties of the two main cell populations that can be isolated from AM: human amniotic mesenchymal stromal cells (hAMSCs) and human amniotic epithelial cells (hAECs). Within the umbilical cord, several compartments have been described, including the amniotic compartment, the Wharton’s jelly (WJ) compartment, and the vascular and perivascular compartment, but herein attention is focused on the properties of human WJ MSCs (hWJMSCs). Since different isol…