Development of biosensors for detection of alpha-fetoprotein: As a major biomarker for hepatocellular carcinoma

Abstract Alpha-fetoprotein as a multifunctional glycoprotein with a dual regulatory role in cancer and fetal activities is belonging to an albuminoid gene family. Due to important biological activities of alpha-fetoprotein in the adjustment of cancer, the level of this biomarker, majorly in liver carcinomas, abnormally is elevated. Also, the probability of high-risk or low-risk patients for chromosomal abnormalities can be identified by the serum level of alpha-fetoprotein. The detection of biomarkers possesses an important role in prognosis and early diagnosis of cancer and other diseases. So, the development of accurate and sensitive methods for measurement of alpha-fetoprotein is of grea…