0000000000407253
AUTHOR
Yong Li
Updated determination of D0–D¯0 mixing and CP violation parameters with D0→K+π− decays
We report measurements of charm-mixing parameters based on the decay-time-dependent ratio of D0→K+π- to D0→K-π+ rates. The analysis uses a data sample of proton-proton collisions corresponding to an integrated luminosity of 5.0 fb-1 recorded by the LHCb experiment from 2011 through 2016. Assuming charge-parity (CP) symmetry, the mixing parameters are determined to be x′2=(3.9±2.7)×10-5, y′=(5.28±0.52)×10-3, and RD=(3.454±0.031)×10-3. Without this assumption, the measurement is performed separately for D0 and D¯0 mesons, yielding a direct CP-violating asymmetry AD=(-0.1±9.1)×10-3, and magnitude of the ratio of mixing parameters 1.00<|q/p|<1.35 at the 68.3% confidence level. All results incl…
Observation of charmless baryonic decays B(s)0→pp¯h+h′−
Decays of B0 and Bs0 mesons to the charmless baryonic final states pp¯h+h′-, where h and h′ each denote a kaon or a pion, are searched for using the LHCb detector. The analysis is based on a sample of proton-proton collision data collected at center-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb-1. Four-body charmless baryonic Bs0 decays are observed for the first time. The decays Bs0→pp¯K+K-, Bs0→pp¯K±π∓, B0→pp¯K±π∓ and B0→pp¯π+π- are observed with a significance greater than 5 standard deviations; evidence at 4.1 standard deviations is found for the B0→pp¯K+K- decay and an upper limit is set on the branching fraction for Bs0→pp¯π+π-. Branching fraction…
Precision Measurement ofCPViolation inBS0→J/ΨK+K−Decays
The time-dependent CP asymmetry in B-S(0) -> J/Psi K+K- decays is measured using pp collision data, corresponding to an integrated luminosity of 3.0 fb(-1), collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV. In a sample of 96 000 B-S(0) -> J/Psi K+K- decays, the CP-violating phase phi(s) is measured, as well as the decay widths GL and GH of the light and heavy mass eigenstates of the B-s(0)-(B) over bar (0)(s) system. The values obtained are phi(s) = -0.058 +/- 0.049 +/- 0.006 rad, Gamma(s) equivalent to (Gamma(L) + Gamma(H))/2 = 0.6603 +/- 0.0027 +/- 0.0015 ps(-1), and Delta Gamma(s) equivalent to Gamma(L)-Gamma(H) = 0.0805 +/- 0.0091 +/- 0.0032 ps(-1), where the f…
Altered functional connectivity in blepharospasm/orofacial dystonia
Abstract Introduction Blepharospasm is characterized by involuntary eyelid spasms. It can be associated with perioral dystonia (Meige's syndrome or orofacial dystonia). We aimed at studying resting‐state functional brain connectivity in these patients and its potential modulation by therapeutic botulinum toxin injections. Methods We performed resting‐state functional MRI and a region of interest‐based analysis of functional connectivity in 13 patients with blepharospasm/Meige's syndrome in comparison to 13 healthy controls. Patients were studied before and 4 weeks after botulinum toxin treatment. Simultaneous facial electromyography was applied to control for involuntary facial movements. R…
Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (P = 2.4 × 10−10). Gene-by-diabetes interactions were…
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation o…
Measurements of charm mixing and CP violation using D0→K±π∓ decays
Measurements of charm mixing and CP violation parameters from the decay-time-dependent ratio of D0→K+π− to D0→K−π+ decay rates and the charge-conjugate ratio are reported. The analysis uses B¯¯¯¯→D∗+μ−X, and charge-conjugate decays, where D∗+→D0π+, and D0→K∓π±. The pp collision data are recorded by the LHCb experiment at center-of-mass energies s√ = 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb−1. The data are analyzed under three hypotheses: (i) mixing assuming CP symmetry, (ii) mixing assuming no direct CP violation in the Cabibbo-favored or doubly Cabibbo-suppressed decay amplitudes, and (iii) mixing allowing either direct CP violation and/or CP violation in the superpos…