0000000000407568
AUTHOR
Santiago Figueroa
Tumor expression levels of CSC markers in resectable non-small cell lung cancer.
7562 Background: Cancer stem cells (CSCs) have been proposed as the driving force of tumorigenesis and the seeds of metastases. However, their existence and role remain a topic of intense debate. T...
Metástasis pulmonares precoces y tardías de fibrohistiocitoma maligno. Tratamiento quirúrgico
Resumen El fibrohistiocitoma maligno (FHM) constituye la variante histologica del grupo de los sarcomas de partes blandas mas frecuente diagnosticada en el adulto. Es una neoplasia poco comun que se localiza, generalmente, en las extremidades inferiores. Son tumores agresivos, con gran tendencia a la recidiva local y a las metastasis sistemicas tardias. El pulmon y el higado son las localizaciones mas frecuentes. Presenta supervivencias cortas. La cirugia radical es el tratamiento de eleccion. Los pacientes con metastasis pulmonares se benefician de la cirugia. Actualmente la ablacion con radiofrecuencia (RFA) de las metastasis pulmonares es una opcion terapeutica en pacientes en los que la…
Isolation and characterization of lung cancer sphere-forming cells as platforms for the development of new therapeutic strategies
e22190 Background: Resistance to treatment is one of major causes influencing the high mortality of lung cancer. This feature seems to be dependent of a minority of cancer cells with special charac...
Ratios between VEGF ligands and receptors in tumor and stroma have impact on the outcome in resectable NSCLC.
e22147 Background: In tumor angiogenesis there is a complex interplay between endothelial, stromal and tumor cells. Some key regulators of this process are the members of the vascular endothelial growth factor (VEGF) family of ligands and receptors and the neuropilins (NRP). This study analyzes the correlations between the expression of these angiogenic factors in tumor cells and tumor stroma, and their prognostic role in tissue samples from resected non-small cell lung cancer (NSCLC) patients. Methods: Representative tumor and stroma areas from FFPE tissue samples of 125 early-stage NSCLC patients were carefully micro-dissected. RNA isolated from the samples was retrotranscripted and prea…