0000000000408008

AUTHOR

Paolo Declich

showing 2 related works from this author

Anti-tumour necrosis factor-α antibodies and B cell homeostasis in human inflammatory bowel diseases

2017

Background The expression of CD70 on T cells is greatly enhanced by antigen-presenting cell (APC)-associated signals, such as tumour necrosis factor(TNF)-α, which is constitutionally high in patients with inflammatory bowel disease (IBD). Experimentally, the chronic activation of CD27 as a result of the constitutive expression of CD70 leads to the demise of B cells in bone marrow (BM) and the secondary lymphoid organs. The aim of this study was to assess the number and phenotype of circulating B cell in untreated IBD patients and their counterparts treated with biological anti-TNF drugs. Methods The study involved 13 untreated IBD patients, 36 IBD patients treated with biological drugs, and…

Male0301 basic medicineT-LymphocytesImmunophenotypingB cell homeostasisBiological drugs; Inflammatory bowel diseases; Plasmablasts; TNF-αHomeostasisImmunology and AllergyCD20B-LymphocytesbiologyB-LymphocyteAntibodies MonoclonalMiddle AgedFlow Cytometrymedicine.anatomical_structureFemaleTumor necrosis factor alphaImmunotherapyAntibodyPlasmablastsHumanAdultAdolescentBiological drugImmunologyB-Lymphocyte SubsetsPlasmablastCD19ImmunophenotypingYoung Adult03 medical and health sciencesHomeostasimedicineHumansBiological drugsB cellB-Lymphocyte SubsetPharmacologyTumor Necrosis Factor-alphabusiness.industryInflammatory Bowel DiseaseInflammatory Bowel Diseases030104 developmental biologyT-LymphocyteTNF-αImmunologybiology.proteinBone marrowbusinessCD27 LigandInternational Immunopharmacology
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Significance of serum Il-9 levels in inflammatory bowel disease

2015

IL-9, which may be an inflammatory or regulatory cytokine, can be experimentally produced in a Th17 or modified Th2 context in the presence of T cell receptor (TCR) stimulation. The primary aim of this study was to measure serum IL-9 levels in patients with inflammatory bowel disease (IBD), and evaluate their relationships with the patients’ clinical characteristics. The secondary aim was to determine the levels of interferon-γ (IFN (interferon)-γ), Th2 cytokines (IL-4, IL-5 and IL-13), and IL-6 in order to clarify the context of detectable peripheral cytokines in which IL-9 is produced. Venous blood samples of 43 IBD patients (20 with Crohn’s disease [CD] and 23 with ulcerative colitis [U…

AdultMaleAdolescentmedicine.medical_treatmentImmunologyPopulationContext (language use)lymphocyteInflammatory bowel diseaseTh17 CellTh2 CellsmedicineImmunology and AllergyHumansInterleukin 9educationInterleukin 6Pharmacologyeducation.field_of_studybiologyinflammation; inflammatory bowel disease; interleukin; lymphocyte homing; lymphocytes; mucosal immunity; Adolescent; Adult; Female; Humans; Inflammatory Bowel Diseases; Interleukin-6; Interleukin-9; Male; Middle Aged; Th17 Cells; Th2 Cells; Immunology and Allergy; Immunology; Pharmacologybusiness.industryinterleukinInterleukin-6Inflammatory Bowel DiseaseInterleukin-9Middle Agedmedicine.diseaseInflammatory Bowel DiseasesUlcerative colitisCytokineinflammationImmunologybiology.proteinTh17 Cellsmucosal immunityFemalelymphocyte homingAntibodybusinessHuman
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