0000000000408009

AUTHOR

Caterina Defendenti

showing 5 related works from this author

Anti-tumour necrosis factor-α antibodies and B cell homeostasis in human inflammatory bowel diseases

2017

Background The expression of CD70 on T cells is greatly enhanced by antigen-presenting cell (APC)-associated signals, such as tumour necrosis factor(TNF)-α, which is constitutionally high in patients with inflammatory bowel disease (IBD). Experimentally, the chronic activation of CD27 as a result of the constitutive expression of CD70 leads to the demise of B cells in bone marrow (BM) and the secondary lymphoid organs. The aim of this study was to assess the number and phenotype of circulating B cell in untreated IBD patients and their counterparts treated with biological anti-TNF drugs. Methods The study involved 13 untreated IBD patients, 36 IBD patients treated with biological drugs, and…

Male0301 basic medicineT-LymphocytesImmunophenotypingB cell homeostasisBiological drugs; Inflammatory bowel diseases; Plasmablasts; TNF-αHomeostasisImmunology and AllergyCD20B-LymphocytesbiologyB-LymphocyteAntibodies MonoclonalMiddle AgedFlow Cytometrymedicine.anatomical_structureFemaleTumor necrosis factor alphaImmunotherapyAntibodyPlasmablastsHumanAdultAdolescentBiological drugImmunologyB-Lymphocyte SubsetsPlasmablastCD19ImmunophenotypingYoung Adult03 medical and health sciencesHomeostasimedicineHumansBiological drugsB cellB-Lymphocyte SubsetPharmacologyTumor Necrosis Factor-alphabusiness.industryInflammatory Bowel DiseaseInflammatory Bowel Diseases030104 developmental biologyT-LymphocyteTNF-αImmunologybiology.proteinBone marrowbusinessCD27 LigandInternational Immunopharmacology
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B lymphocyte intestinal homing in inflammatory bowel disease.

2011

Abstract Background Inflammatory bowel disease (IBD) is thought to be due to an abnormal interaction between the host immune system and commensal microflora. Within the intestinal immune system, B cells produce physiologically natural antibodies but pathologically atypical anti-neutrophil antibodies (xANCAs) are frequently observed in patients with IBD. The objective is to investigate the localisation of immunoglobulin-producing cells (IPCs) in samples of inflamed intestinal tissue taken from patients with IBD, and their possible relationship with clinical features. Methods The IPCs in small intestinal, colonic and rectal biopsy specimens of patients with IBD were analysed by means of immun…

lcsh:Immunologic diseases. AllergylymphocytesAdultMalePathologymedicine.medical_specialtyLymphocyteBiopsyImmunologyFluorescent Antibody TechniqueInflammatory bowel diseaseImmunophenotypingImmunomodulationImmune systemAntigens CDCell Movementinflammatory bowel diseasemedicineHumansB1 cells; Inflammation; Inflammatory bowel disease; Lymphocyte homing; Lymphocytes; Mucosal immunity; Adult; Aged; Antigens CD; B-Lymphocytes; Biopsy; Cell Differentiation; Cell Movement; Female; Fluorescent Antibody Technique; Humans; Immunoglobulin M; Immunomodulation; Immunophenotyping; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Middle Aged; ImmunologyIntestinal MucosaB cellAgedB-LymphocytesbiologyB1 cellsCell DifferentiationMiddle Agedmedicine.diseaseInflammatory Bowel DiseasesUlcerative colitisB-1 cellIntestinesmedicine.anatomical_structureImmunoglobulin MinflammationImmunologybiology.proteinmucosal immunityFemalelymphocyte homingCD5Antibodylcsh:RC581-607Research Article
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Unusual B cell morphology in inflammatory bowel disease.

2012

B lymphocytes express various different types of surface immunoglobulins that are largely unrelated to other hematological lines, although some reports have described a relationship between malignant B cells and other cells such as macrophages. Multiple genes of hematopoietic lineage, including transcription factors, are co-expressed in hematopoietic stem cells and progenitors, a phenomenon referred to as "lineage priming". Changes in the expression levels and timing of transcription factors can induce the lineage conversion of committed cells, which indicates that the regulation of transcription factors might be particularly critical for maintaining hierarchical hematopoietic development. …

MalePathologyCD79BiopsyUlcerativeSmallInflammatory bowel diseaseInflammatory bowel diseaseMucosal immunityCrohn DiseaseIntestine SmallLymphocytesMicroscopyB-Lymphocytesmedicine.diagnostic_testMiddle AgedColitisFucosyltransferasesIntestineSurfaceHaematopoiesismedicine.anatomical_structureAntigens SurfaceFemaleStem cellB-1 B cellsAdultmedicine.medical_specialtyLymphocyte homingColonLewis X AntigenBiologyFluorescencePathology and Forensic MedicineAntigeninflammatory bowel diseaseBiopsymedicineHumansCell LineageProgenitor cellAntigensB cellInflammatory bowel disease; Inflammation; Mucosal immunity; Lymphocytes; B-1 B cells; Lymphocyte homing; CD15+cells; Adult; Antigens Surface; B-Lymphocytes; Biomarkers; Biopsy; Cell Lineage; Cell Nucleus; Colitis Ulcerative; Colon; Crohn Disease; Female; Fucosyltransferases; Humans; Immunoglobulin M; Inflammatory Bowel Diseases; Intestine Small; Lewis X Antigen; Male; Microscopy Fluorescence; Middle Aged; RectumInflammationCell NucleusRectumCell Biologymedicine.diseaseInflammatory Bowel DiseasesImmunoglobulin MMicroscopy FluorescenceImmunologyColitis UlcerativeCD15+cellsBiomarkersPathology, research and practice
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Significance of serum Il-9 levels in inflammatory bowel disease

2015

IL-9, which may be an inflammatory or regulatory cytokine, can be experimentally produced in a Th17 or modified Th2 context in the presence of T cell receptor (TCR) stimulation. The primary aim of this study was to measure serum IL-9 levels in patients with inflammatory bowel disease (IBD), and evaluate their relationships with the patients’ clinical characteristics. The secondary aim was to determine the levels of interferon-γ (IFN (interferon)-γ), Th2 cytokines (IL-4, IL-5 and IL-13), and IL-6 in order to clarify the context of detectable peripheral cytokines in which IL-9 is produced. Venous blood samples of 43 IBD patients (20 with Crohn’s disease [CD] and 23 with ulcerative colitis [U…

AdultMaleAdolescentmedicine.medical_treatmentImmunologyPopulationContext (language use)lymphocyteInflammatory bowel diseaseTh17 CellTh2 CellsmedicineImmunology and AllergyHumansInterleukin 9educationInterleukin 6Pharmacologyeducation.field_of_studybiologyinflammation; inflammatory bowel disease; interleukin; lymphocyte homing; lymphocytes; mucosal immunity; Adolescent; Adult; Female; Humans; Inflammatory Bowel Diseases; Interleukin-6; Interleukin-9; Male; Middle Aged; Th17 Cells; Th2 Cells; Immunology and Allergy; Immunology; Pharmacologybusiness.industryinterleukinInterleukin-6Inflammatory Bowel DiseaseInterleukin-9Middle Agedmedicine.diseaseInflammatory Bowel DiseasesUlcerative colitisCytokineinflammationImmunologybiology.proteinTh17 Cellsmucosal immunityFemalelymphocyte homingAntibodybusinessHuman
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Morphological distribution of μ chains and cd15 receptors in colorectal polyp and adenocarcinoma specimens

2013

BACKGROUND: We have recently investigated the localisation of immunoglobulin-producing cells (IPCs) in inflamed intestinal tissue samples from patients with inflammatory bowel disease (IBD), and identified two main patterns of B lymphocyte infiltration: one characterised by the moderate strong stromal localisation of small B1 cell-like IgM+/CD79+/CD20-/CD21-/CD23-/CD5 ± IPCs, and the other by the peri-glandular localisation of IPCs with irregular nuclei that had surface markers specific for a B cell subset (IgM and CD79), but quantitative differences in their λ and κ chains. The same patients were also tested for CD15+ receptors, which were localised on inflammatory cell surfaces or in the …

Sialyl-LewisXPathologymedicine.medical_specialtyHistologyStromal cellCD792734B-1 cells; Colorectal adenocarcinoma; Inflammatory bowel disease; Matrix metalloproteinases; Sialyl-LewisX; 2734; HistologyCell morphologyImmunofluorescencecolorectal polyp and adenocarcinomaInflammatory bowel diseaseColorectal adenocarcinomaPathology and Forensic MedicineB-1 cellsmedicineReceptorB cellImmunoperoxidasemedicine.diagnostic_testbusiness.industrymedicine.diseaseMatrix metalloproteinasesmedicine.anatomical_structureAdenocarcinomabusinessResearch ArticleBMC Clinical Pathology
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