Time for a Step Change? Improving the Efficiency, Relevance, Reliability, Validity and Transparency of Aphasia Rehabilitation Research through Core Outcome Measures, a Common Data Set and Improved Reporting Criteria
Considered and meticulous outcome measurement is central to rigorously conducted effectiveness trials, and in turn the relevance and reliability of the study findings to the patient, therapist or p...
Rivaroxaban for thromboprophylaxis in acutely ill medical patients.
International audience; BACKGROUND: The clinically appropriate duration of thromboprophylaxis in hospitalized patients with acute medical illnesses is unknown. In this multicenter, randomized, double-blind trial, we evaluated the efficacy and safety of oral rivaroxaban administered for an extended period, as compared with subcutaneous enoxaparin administered for a standard period, followed by placebo. METHODS: We randomly assigned patients 40 years of age or older who were hospitalized for an acute medical illness to receive subcutaneous enoxaparin, 40 mg once daily, for 10±4 days and oral placebo for 35±4 days or to receive subcutaneous placebo for 10±4 days and oral rivaroxaban, 10 mg onc…