0000000000409657
AUTHOR
Jinhee Kim
Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensiti…
Non-Local Transport in a Multi-Wall Carbon Nanotube
Non-local electric transport phenomena were observed for a multi-wall carbon nanotube. The magnetic field dependence of non-local resistance was out of phase with respect to the conventional four-probe resistance, which could be explained in terms of the Landauer-Buttiker formula. Our observations indicate that the phase coherence length of multi-wall carbon nanotube exceeds the voltage probe length of about 1.1 µm at the measured temperatures.