0000000000409657

AUTHOR

Jinhee Kim

showing 2 related works from this author

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

2017

Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensiti…

0301 basic medicinevirusesFAMILY INHIBITORSlcsh:QR1-502Virus Replicationlcsh:Microbiologychemistry.chemical_compoundTranscription (biology)SALIPHENYLHALAMIDEhost responseTRANSCRIPTIONprogrammed cell deathinnate immunity1183 Plant biology microbiology virologySulfonamidesAniline CompoundsapoptosisTransfection3. Good healthInfectious DiseasesProto-Oncogene Proteins c-bcl-2X-L INHIBITORVirus DiseasesvirustauditVirusesRNA ViralBiologyTransfectionta3111Antiviral AgentsArticleCell LineMicrobiology in the medical areaantiviral agent03 medical and health sciencesohjelmoitunut solukuolemaVirologyMikrobiologi inom det medicinska områdetHumansMetabolomicsBenzothiazolesInnate immune systemapoptosis; antiviral agent; innate immunity; host responseZIKA VIRUS-INFECTIONCHRONIC LYMPHOCYTIC-LEUKEMIAPOTENTta1183INFLUENZA-Ata1182RNAIsoquinolinesVirology030104 developmental biologyViral replicationchemistryCell cultureApoptosisCELLSREPLICATIONDNA Viral3111 BiomedicineDNA
researchProduct

Non-Local Transport in a Multi-Wall Carbon Nanotube

2001

Non-local electric transport phenomena were observed for a multi-wall carbon nanotube. The magnetic field dependence of non-local resistance was out of phase with respect to the conventional four-probe resistance, which could be explained in terms of the Landauer-Buttiker formula. Our observations indicate that the phase coherence length of multi-wall carbon nanotube exceeds the voltage probe length of about 1.1 µm at the measured temperatures.

NanotubeMaterials scienceCondensed matter physicsMagnetoresistanceGeneral Physics and Astronomychemistry.chemical_elementCarbon nanotubeCondensed Matter::Mesoscopic Systems and Quantum Hall EffectNon locallaw.inventionMagnetic fieldCarbon nanotube quantum dotchemistrylawCarbonVoltageJournal of the Physical Society of Japan
researchProduct