0000000000410234

AUTHOR

Andreas G. Tzakis

showing 2 related works from this author

Uterus transplantation: animal research and human possibilities

2012

Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation. The animal research on uterus transplantation conducted during the past two decades is summarized, and we describe our views regarding a future research-based human attempt.

Uterine DiseasesInfertilityGynecologymedicine.medical_specialtybusiness.industryGeneral surgeryUterusUterusObstetrics and GynecologyOrgan Transplantationmedicine.diseaseTransplantationmedicine.anatomical_structureReproductive MedicineModels AnimalUterus transplantationAnimalsHumansMedicineFemalebusinessInfertility FemaleFertility and Sterility
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Preclinical report on allogeneic uterus transplantation in non-human primates

2013

Study question Is it possible to perform allogeneic uterus transplantation (UTx) with a donation from a live donor in a non-human primate species and what immunosuppression is needed to prevent rejection? Summary answer Allogeneic UTx in the baboon is a donor- and recipient-safe surgical procedure; immunosuppression with induction therapy and a triple protocol should be used. What is known already UTx may become a treatment for absolute uterine factor infertility. Autologous UTx models have been developed in non-human primates with reports on long-term survival of the uterine grafts. STUDY DESIGN, SIZEAND DURATION: This experimental study included 18 female baboons as uterus donors and 18 f…

Graft Rejectionmedicine.medical_specialtymedicine.medical_treatmentUterusTacrolimusMaintenance ChemotherapyAdrenal Cortex Hormonesmedicine.arteryUterus transplantationmedicineLiving DonorsAnimalsTransplantation HomologousExternal iliac veinAntilymphocyte SerumImmunosuppression TherapyUterine DiseasesHysterectomybusiness.industryRehabilitationGraft SurvivalUterusObstetrics and GynecologyImmunosuppressionInduction ChemotherapyMycophenolic AcidInternal iliac arteryTacrolimusSurgeryTransplantationDisease Models Animalmedicine.anatomical_structureReproductive MedicineFeasibility StudiesDrug Therapy CombinationFemalebusinessInfertility FemalePapio
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