High fat-high fructose diet triggered metabolic syndrome and retinal neovascular complications in the rat

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.; Purpose : On the contrary to type II diabetes, the consequences of metabolic syndrome (MetS) in the retina are poorly documented. MetS includes insulin resistance, glucose intolerance, dyslipidemia and abdominal adiposity. Vascular changes are strongly associated to metabolic diseases. Thus, we tested the hypothesis that feeding rats with high fructose (60%) and high fat (10%) would contribute to the development of MetS and neovascular retinal complications.Methods : Male Brown Norway rats (6 weeks of age) were fed with a regular chow diet or a 60% rich fructose+10% lipid-rich di…