0000000000413549
AUTHOR
ŁUkasz Moos
Diabetic Peripheral Neuropathy is Associated With Diabetic Kidney Disease and Cardiovascular Disease:The Silesia Diabetes-Heart Project
Microvascular complications of diabetes seem to be clustered and put patients at higher risk of developing cardiovascular disease (CVD). This was a questionnaire-based study designed to screen for the presence of diabetic peripheral neuropathy (DPN), defined as the score in the Michigan Neuropathy Screening Instrument (MNSI) above 2, and to evaluate its association with other complication of diabetes, including CVD. There were 184 patients included into the study. The prevalence of DPN in the study group was 37.5%. The regression model analysis revealed that the presence of DPN was significantly associated with the presence of diabetic kidney disease (DKD) (P = 0.0034;) and patient's age (P…
Szczepienie przeciw COVID-19 przy podejrzeniu anafilaksji po pierwszej dawce szczepionki
Wraz z rosnącą liczbą wykonanych szczepień przeciwko COVID-19 (p/COVID-19) wzrasta także liczba zgłaszanych reakcji o różnym obrazie klinicznym po podaniu szczepionki. Mimo że reakcje te występują stosunkowo rzadko i nie zawsze mają charakter alergiczny, to budzą lęk. Szczególnie pacjenci, którzy doznali działań niepożądanych szczepienia, często nie są kwalifikowani do podania kolejnych dawek tym samym preparatem. Rozpoznanie ciężkiej reakcji anafilaktycznej po podaniu szczepionki mRNA i/lub uczulenie na jej składniki są przeciwwskazaniami do szczepienia preparatem mRNA p/COVID-19.
 Prezentowany przypadek pacjentki przedstawia problem prawidłowej kwalifikacji reakcji, które miały miejs…
The Role of Interleukin 10 and 18 in Chronic Spontaneous Urticaria Pathogenesis in the Context of Angioedema Coexistence
Chronic spontaneous urticaria (CSU) is defined using clinical symptoms as spontaneous occurrence of itchy wheals and/or angioedema for at least 6 weeks. Angioedema is underdiagnosed in CSU patients, and its presence has significant negative impact on health-related quality of life, daily activities, health care resource utilization, and work. Various cytokines have been found to be involved in pathogenesis of CSU. To study levels of interleukin (IL)-10 and IL-18 in CSU patients and to look for the differences in CSU subgroups divided with regard to angioedema reoccurrence, we included consecutive CSU patients into the study. To assess disease activity, urticaria activity score was used. In …
Exhaled Nitric Oxide Level in Pharynx Angioedema.
Airway inflammation is related to increased nitric oxide production. It can be assessed noninvasively with exhaled nitric oxide measurement. As airway inflammation was supposed to be present in chronic urticaria and angioedema patients we hypothesized increased exhaled nitric oxide in this group. Twenty-six symptomatic chronic urticaria patients with an acute episode of pharynx angioedema (17 women and 9 men, median age 35) were included in the study group. None of the patients reported a history of asthma, allergic rhinitis or cigarette smoking. The control group consisted of 29 non-smoking healthy subjects (19 women and 10 men, median age 22) without any history of atopy. Exhaled nitric o…
From suspicion of angioedema to the diagnosis of lung cancer
Angioedema is a localized and self-limiting oedema of the subcutaneous and submucosal tissue. Case presentation: 73-year-old man was admitted to the Division of Allergology with the diagnosis of angioedema. Detailed physical examination led to the suspicion of superior vena cava syndrome with secondary face swelling. Biopsy revealed metastasis of small cell carcinoma in superclavicular lymph nodes. Conclusions: Facial swelling, especially recurrent and non-inflammatory, is often, but not always caused by angioedema. Insightful differential diagnosis is crucial before making the final one.
Can smoking have a positive effect on the course of certain diseases? A systematic review
Background: Smoking cigarettes is a process during which many harmful substances are introduced into the lungs and the influence of these substances on the human body is not completely known. There are many diseases caused by smoking. Interestingly, there are also reports of positive consequences of smoking on some disorders. Aim of the study: The purpose of this article is to review the literature in regards to the diseases in which cigarettes might have a paradoxically beneficial effect — both on the onset and their course. We also want to focus on the mechanisms responsible for this impact. Material and Methods: Electronic searching of PubMed was performed. We analyzed articles published…