0000000000413583

AUTHOR

Ralf Smeets

showing 4 related works from this author

Investigation of inhibitory effects on EPC-mediated neovascularization by different bisphosphonates for cancer therapy.

2013

Bisphosphonates (BPs) are potent drugs, used in metastatic cancer-like prostate or breast carcinoma. In recent studies, besides reduced bone remodeling, influences on angiogenesis and neovascularization were reported. Since BPs have the tendency to accumulate in the bones, the biological effect of various nitrogen- and non-nitrogen BPs on endothelial progenitor cells (EPCs) that originated from bone marrow and mobilized under physiological and pathophysiological conditions, such as tumor neovascularization, was investigated. EPCs subsequent to 72-h treatment with different concentrations of bisphosphonates comprised the non-nitrogen-containing BP clodronate and the nitrogen-containing BPs i…

business.industryAngiogenesisGeneral Neurosciencemedicine.medical_treatmentContext (language use)General MedicineArticlesBisphosphonateurologic and male genital diseasesEndothelial progenitor cellGeneral Biochemistry Genetics and Molecular BiologyBone remodelingNeovascularizationmedicine.anatomical_structureImmunologymedicineCancer researchBone marrowGeneral Pharmacology Toxicology and Pharmaceuticsmedicine.symptomProgenitor cellbusinesshormones hormone substitutes and hormone antagonistsBiomedical reports
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Ability of nanocrystalline hydroxyapatite paste to promote human periodontal ligament cell proliferation.

2008

Recent studies indicate that nanocrystalline hydroxyapatite (nano-HA) paste represents a promising class of bone graft substitute. However, the underlying molecular mechanisms of nano-HA function have not yet been determined. This study was conducted to investigate the proliferation of human periodontal ligament (PDL) cells cultured in the presence of nano-HA paste and to characterize associated changes in intracellular signaling pathways. Cultured PDL cells were stimulated with nano-HA paste and enamel matrix derivative (EMD) in a soluble form. Proliferation of PDL cells was determined by incorporation of bromodeoxyuridine (BrdU) in the DNA of proliferating cells. In order to understand th…

MAPK/ERK pathwayPeriodontal LigamentBlotting Westernchemistry.chemical_compoundDental Enamel ProteinsPeriodontal fiberHumansRegenerationEpidermal growth factor receptorPhosphorylationGeneral DentistryProtein kinase BCells CulturedCell ProliferationMitogen-Activated Protein Kinase 1biologyChemistryCell growthKinaseAnatomyFibroblastsCell biologyErbB ReceptorsDurapatiteBone Substitutesbiology.proteinPhosphorylationNanoparticlesProto-Oncogene Proteins c-aktBromodeoxyuridineJournal of oral science
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Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes

2018

The following article: Jung, R.E., Al-Nawas, B., Araujo, M., Avila-Ortiz, G., Barter, S., Brodala, N., ... Windisch, P. (2018). Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes. Clinical Oral Implants Research, 29(S16), 69-77, can be accessed at https://doi.org/10.1111/clr.13342. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Objectives: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient‐re…

medicine.medical_treatmentOsteoporosisbiological complicationsDentistryOsteoporosis/complicationsmeta-analysilaw.inventionProton Pump Inhibitors/adverse effects0302 clinical medicineRandomized controlled triallawRadiography DentalDental Restoration FailureDental implanthumans610 Medicine & healthclinical decision-makingdental implantDiphosphonatesnarrow diameter3504 Oral SurgeryJaw Edentulous Partially05 social sciencesDental Implantation EndosseousImplant failuredrugsmall dental implantVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830failureclinical decision‐makingDiphosphonates/adverse effectsMeta-analysisrandomized controlled trials/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingepidemiologymedicationOral SurgerySelective Serotonin Reuptake InhibitorsConsensusreview610 Medicine & healthsurvival03 medical and health sciences10068 Clinic of Reconstructive DentistrySDG 3 - Good Health and Well-beingdental implants0502 economics and businessmedicineshort dental implantsHumansbiological complicationPatient Reported Outcome MeasureshumanSurvival ratesmall dental implantsDental Implantsbusiness.industryJaw Edentulous Partially/rehabilitationshort dental implantProton Pump Inhibitors030206 dentistrymedicine.diseaseendosseous implantSurvival AnalysisVDP::Medical disciplines: 700::Clinical dentistry disciplines: 830Dental Prosthesis Designmeta‐analysisRelative riskrandomized controlled trialOsteoporosis050211 marketingImplantSerotonin Uptake Inhibitors/adverse effectsbusinessosteotomySystematic Reviews as Topic
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Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner – A quantitative in vitro gene expression analy…

2010

Bisphosphonates are widely used in the clinical treatment of bone diseases with increased bone resorption. In terms of side effects, they are known to be associated with osteonecrosis of the jaw (BONJ). There are two groups of bisphosphonates: the nitrogen-containing bisphosphonates, e.g. zoledronate and ibandronate, and the non-nitrogen-containing bisphosphonates, e.g. clodronate. Their impact on bone metabolism seems to differ. The objective of this study was to compare the osteogenic differentiation potency of these two pharmacologic groups. Human osteoblasts were stimulated with zoledronate and ibandronate at concentrations of 5×10(-5) M, 5×10(-6) M and 5×10(-7) M over the experimental …

medicine.medical_specialtyTime Factorsmedicine.medical_treatmentOsteocalcinCell Culture TechniquesCore Binding Factor Alpha 1 SubunitZoledronic AcidIbandronic acidBone remodelingInternal medicineHumansMedicineIbandronic AcidHomeodomain ProteinsMSX1 Transcription FactorOsteoblastsBone Density Conservation AgentsDiphosphonatesDose-Response Relationship DrugbiologyReverse Transcriptase Polymerase Chain Reactionbusiness.industryImidazolesCell DifferentiationOsteoblastDLX5BisphosphonateRUNX2Zoledronic acidmedicine.anatomical_structureEndocrinologyGene Expression RegulationOtorhinolaryngologyOsteocalcinbiology.proteinSurgeryBone RemodelingClodronic AcidOral SurgerybusinessBiomarkersTranscription Factorsmedicine.drugJournal of Cranio-Maxillofacial Surgery
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