Comparison of Sulfur Hexafluoride Microbubble (SonoVue)-Enhanced Myocardial Contrast Echocardiography With Gated Single-Photon Emission Computed Tomography for Detection of Significant Coronary Artery Disease
Objectives The purpose of this study was to compare sulfur hexafluoride microbubble (SonoVue)-enhanced myocardial contrast echocardiography (MCE) with single-photon emission computed tomography (SPECT) relative to coronary angiography (CA) for assessment of coronary artery disease (CAD). Background Small-scale studies have shown that myocardial perfusion assessed by SonoVue-enhanced MCE is a viable alternative to SPECT for CAD assessment. However, large multicenter studies are lacking. Methods Patients referred for myocardial ischemia testing at 34 centers underwent rest/vasodilator SonoVue-enhanced flash-replenishment MCE, standard Tc-99m-labeled electrocardiography-gated SPECT, and quanti…
016: Evidence of systemic plaque vulnerability in acute coronary syndromes with FDG-positron emission tomography and computed tomographic angiography in the BIOCORE-2 study
PurposeAtherosclerotic plaque vulnerability is a systemic phenomenon and is often associated with severe plaque infiltration with inflammatory cells. 18-Fluoro-deoxyglucose (FDG) accumulates in inflammatory cells of atherosclerotic plaques. The aim of this study was to assess whether 1) FDG uptake in the aorta and carotid arteries measured by positron emission tomography (PET) is higher in patients with acute coronary syndromes (ACS) than in patients with stable coronary artery disease (CAD) and; 2) associated with morphological markers of plaque instability detected with computed tomography angiography (CTA).MethodsPatients with ACS (n=50) or stable CAD (n=28) underwent a PET 90 minutes af…