0000000000414154

AUTHOR

Fernando Mosteiro

showing 4 related works from this author

Stratification for Identification of Prognostic Categories In the Acute RESpiratory Distress Syndrome (SPIRES) Score.

2021

OBJECTIVES: To develop a scoring model for stratifying patients with acute respiratory distress syndrome into risk categories (Stratification for identification of Prognostic categories In the acute RESpiratory distress syndrome score) for early prediction of death in the ICU, independent of the underlying disease and cause of death. DESIGN: A development and validation study using clinical data from four prospective, multicenter, observational cohorts. SETTING: A network of multidisciplinary ICUs. PATIENTS: One-thousand three-hundred one patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN …

AdultMalemedicine.medical_specialtyOrgan Dysfunction ScoresPsychological interventionMEDLINECritical Care and Intensive Care MedicineLogistic regressionSeverity of Illness IndexstratificationInternal medicinemedicineHumansProspective StudiesCause of deathAPACHEclinical trialsRespiratory Distress SyndromeReceiver operating characteristicbusiness.industryphenotypesscoring systemacute respiratory distress syndromeMiddle AgedPrognosisRespiration ArtificialIntensive Care UnitsROC CurveSpainArea Under CurveCohortBreathingoutcomeObservational studyFemalebusinessCritical care medicine
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A Prognostic Enrichment Strategy for Selection of Patients With Acute Respiratory Distress Syndrome in Clinical Trials.

2019

Incomplete or ambiguous evidence for identifying high-risk patients with acute respiratory distress syndrome for enrollment into randomized controlled trials has come at the cost of an unreasonable number of negative trials. We examined a set of selected variables early in acute respiratory distress syndrome to determine accurate prognostic predictors for selecting high-risk patients for randomized controlled trials.A training and testing study using a secondary analysis of data from four prospective, multicenter, observational studies.A network of multidisciplinary ICUs.We studied 1,200 patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventil…

AdultMalemedicine.medical_specialtyOrgan Dysfunction ScoresMEDLINEAcute respiratory distressCritical Care and Intensive Care Medicinelaw.inventionRandomized controlled triallawMedicineHumansProspective StudiesIntensive care medicineProspective cohort studySelection (genetic algorithm)AgedRandomized Controlled Trials as TopicRespiratory Distress Syndromebusiness.industryPatient SelectionAge FactorsMiddle AgedPrognosisClinical trialMulticenter studyObservational studyFemalebusinessCritical care medicine
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Is Overall Mortality the Right Composite Endpoint in Clinical Trials of Acute Respiratory Distress Syndrome?

2018

Objectives Overall mortality in patients with acute respiratory distress syndrome is a composite endpoint because it includes death from multiple causes. In most acute respiratory distress syndrome trials, it is unknown whether reported deaths are due to acute respiratory distress syndrome or the underlying disease, unrelated to the specific intervention tested. We investigated the causes of death after contracting acute respiratory distress syndrome in a large cohort. Design A secondary analysis from three prospective, multicenter, observational studies. Setting A network of multidisciplinary ICUs. Patients We studied 778 patients with moderate-to-severe acute respiratory distress syndrome…

Malemedicine.medical_specialtyCritical Care and Intensive Care MedicineHypoxemia03 medical and health sciences0302 clinical medicineInternal medicineCause of DeathmedicineHumans030212 general & internal medicineProspective StudiesProspective cohort studyCause of deathRandomized Controlled Trials as TopicRespiratory Distress SyndromeLungbusiness.industryMiddle AgedClinical trialmedicine.anatomical_structure030228 respiratory systemRelative riskCohortBreathingmedicine.symptombusinessCritical care medicine
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Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic r…

2021

Normothermic Regional Perfusion (NRP) allows the in situ perfusion of organs with oxygenated blood in donation after the circulatory determination of death (DCDD). We aimed at evaluating the impact of NRP on the short-term outcomes of kidney transplants in controlled DCDD (cDCDD). This is a multicenter, nationwide, retrospective study comparing cDCDD kidneys obtained with NRP versus the standard rapid recovery (RR) technique. During 2012-2018, 2,302 cDCDD adult kidney transplants were performed in Spain using NRP (n=865) or RR (n=1,437). The study groups differed in donor and recipient age, warm and cold ischemic time and use of ex situ machine perfusion. Transplants in the NRP group were m…

Adultmedicine.medical_specialtyTissue and Organ Procurementdonors and donationdelayed graft function (DGF)graft survivalnephrologyUrologykidney transplantationorgan procurement and allocationRegional perfusion030230 surgery03 medical and health sciences0302 clinical medicineHumansImmunology and AllergyMedicinePharmacology (medical)Retrospective StudiesTransplantationKidneyMachine perfusionorgan perfusion and preservationbusiness.industryGraft SurvivalRetrospective cohort studyOrgan PreservationKidney TransplantationTissue DonorspracticeDelayed Graft FunctionDeathPerfusionmedicine.anatomical_structureclinical researchDonationPropensity score matchingCirculatory systembusinessdonation after circulatory death (DCD)
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