0000000000414343
AUTHOR
Damien Lapray
Stimulus-induced gamma activity in the electrocorticogram of freely moving rats: the neuronal signature of novelty detection.
To investigate the cortical activity pattern associated with the exploration and identification of a novel object we recorded the intracranial electrocorticogram (ECoG) in the barrel cortex of freely moving adult rats using wireless technology. We report here that the exploration and detection of a novel object correlate with a transient increase of synchronized oscillatory activity in the 40–47 Hz frequency band. This specific cortical activity pattern occurs 200–300 ms after the first sensory contact with the novel stimulus and decreases in power in the subsequent recording sessions with the same object. During the first explorative session the increase in 40–47 Hz is associated with a si…
Spontaneous Epileptic Manifestations in a DCX Knockdown Model of Human Double Cortex
Previous reports indicate that in utero knockdown of doublecortin (DCX) results in the genesis of a subcortical heterotopia reminiscent of the doublecortex observed in female patients with DCX mutations. It has also been shown that these rats display an increased susceptibility to convulsant agents and increased cortical neurons excitability; but it is presently unknown whether they display spontaneous seizures. Furthermore, the link between the size of heterotopia and the clinical manifestation remained to be elucidated. Using video--electrocorticogram recordings, we now report that DCX knockdown induces frequent spontaneous seizures commonly associated with myoclonic jerks in adult rats. …
A novel miniature telemetric system for recording EEG activity in freely moving rats
Telemetric recording systems offer the advantage to monitor physiological parameters in freely moving animals without any restrictions in their explorative behaviour. We present a novel, inexpensive, portable and reusable telemetric system to record the electroencephalogram (EEG) from adult freely moving rats under various experimental conditions. Our system consists of an implantable transmitter which communicates at a sampling rate of 500 Hz bi-directional with a receiver via radio transmission (in EU: 868.35 MHz; in USA: 916.5 MHz) over a distance of up to 3 m. The switching time between receiving and transmitting signals is 20s and the data transmission rate amounts to 115.2 kbps. The r…