Author: Jelena Ostojic

0000000000414448

AUTHOR

Jelena Ostojic

Guanidinoacetate-creatine in secondary progressive multiple sclerosis: a case report.

Acute secondary progressive multiple sclerosis (SPMS) is characterized by escalating neurological disability, with limited disease-modifying therapeutic options. A 48-year-old woman with acute SPMS being treated with interferon beta-1a and oral corticosteroids presented as a clinical outpatient with no disease-modifying effects after treatment. A decision was made to treat her with a combination of guanidinoacetate and creatine for 21 days. She had made clinical progress at follow-up, with the intensity of fatigue dropping from severe to mild. Magnetic resonance spectroscopy revealed increased brain choline, creatine, N-acetylaspartate, and glutathione. Patients with SPMS may benefit from …

research product

sj-pdf-1-imr-10.1177_03000605211073305 - Supplemental material for Guanidinoacetate��creatine in secondary progressive multiple sclerosis: a case report

Supplemental material, sj-pdf-1-imr-10.1177_03000605211073305 for Guanidinoacetate��creatine in secondary progressive multiple sclerosis: a case report by Sergej M. Ostojic, Jelena Ostojic, Dragana Zanini, Tatjana Jezdimirovic and Valdemar Stajer in Journal of International Medical Research

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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