0000000000415121

AUTHOR

Emilia Vuttariello

showing 4 related works from this author

Gender- and age-related distinctions for the in vivo prooxidant state in Fanconi anaemia patients.

2004

Abstract Some selected oxidative stress parameters were measured in 56 Fanconi anaemia (FA) patients (42 untransplanted and 14 transplanted), 54 FA heterozygotes (parents) and 173 controls. Untransplanted FA patients showed a highly significant increase in leukocyte 8-hydroxy-2’-deoxyguanosine (8-OHdG) (p = 0.00003) and a borderline increase (p = 0.076) in urinary levels of 8-OHdG vs. child controls. These increases were more pronounced in female FA patients (p = 0.00005 for leukocyte 8-OHdG, and p = 0.021 for urinary 8-OHdG). Female FA patients also displayed a highly significant excess of spontaneous chromosomal breaks vs. male patients (p = 0.00026), in the same female:male ratio (≅ 1.4)…

MaleCancer Researchmedicine.medical_treatmentTransplantsUrineAscorbic Acidmedicine.disease_causechemistry.chemical_compoundLeukocytesChromosomes HumanVitamin EChildRespiratory BurstGlutathione DisulfideAge FactorsChromosome BreakageGeneral MedicinePyruvaldehydeGlutathioneBiochemistry8-Hydroxy-2'-DeoxyguanosineChild PreschoolFemaleOxidation-ReductionAdultmedicine.medical_specialtyHeterozygoteAdolescentUrinary systemBiologySex FactorsInternal medicinemedicineHumansVitamin CVitamin EDeoxyguanosineInfantGlutathioneDNAAscorbic acidUric AcidOxidative StressEndocrinologyFanconi AnemiachemistryCase-Control StudiesUric acidReactive Oxygen SpeciesOxidative stressCarcinogenesis
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Glutathione levels in blood from ataxia telangiectasia patients suggest in vivo adaptive mechanisms to oxidative stress

2007

Objective: To evaluate an in vivo pro-oxidant state in patients with ataxia telangiectasia (AT). Methods: A set of oxidative stress endpoints were measured in 9 AT homozygotes, 16 AT heterozygotes (parents) and 83 controls (grouped in age ranges as for patients and parents, respectively). The following analytes were measured: (a) leukocyte 8-hydroxy-2-deoxyguanosine (8-OHdG); (b) blood glutathione (GSSG and GSH); and (c) plasma levels of glyoxal (Glx) and methylglyoxal (MGlx). Results: AT patients displayed a significant decrease in blood GSSG (p=0.012) and in MGlx plasma concentrations (P=0.012). A nonsignificant decrease in the GSSG:GSH ratio (p = 0.1) and a non-significant increase in 8-…

AdultMalemedicine.medical_specialtyAdolescentglyoxalClinical Biochemistryataxia telengiectasiamedicine.disease_causeAtaxia Telangiectasiachemistry.chemical_compoundIn vivoInternal medicinemethylglyoxalmedicineHumansataxia telangectasiaoxidative stressglutathioneChildoxidative streMethylglyoxalDeoxyguanosine8-Hydroxy-2'-deoxyguanosineHeterozygote advantageGeneral MedicineGlutathionePyruvaldehydemedicine.diseaseAdaptation Physiological8-Hydroxy-2'-deoxyguanosineEndocrinologychemistryBiochemistryChild PreschoolAtaxia-telangiectasiaFemaleataxia telangectasia; oxidative stress; glutathione; glyoxal; methylglyoxal; 8-Hydroxy-2'-deoxyguanosineOxidative stressTarget organDNA DamageClinical Biochemistry
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In vivoprooxidant state in Werner syndrome (WS): Results from three WS patients and two WS heterozygotes

2005

The hypothesis was tested that Werner syndrome (WS) phenotype might be associated with an in vivo prooxidant state. A set of redox-related endpoints were measured in three WS patients, two of their parents, and 99 controls within a study of some cancer-prone and/or ageing-related genetic disorders. The following analytes were measured: (a) leukocyte 8-hydroxy-2'-deoxyguanosine; (b) glutathione from whole blood, and (c) plasma levels of glyoxal, methylglyoxal, 8-isoprostane, and some plasma antioxidants (uric acid, ascorbic acid, alpha- and gamma-tocopherol). Leukocyte 8-hydroxy-2'-deoxyguanosine levels showed a significant increase in the 3 WS patients vs. 85 controls (p<10(-7)). The disulf…

AdultMaleHeterozygotemedicine.medical_specialtyDinoprostmedicine.disease_causeBiochemistryAntioxidantschemistry.chemical_compoundIn vivoInternal medicineLeukocytesmedicineHumansDeoxyguanosineChromatography High Pressure LiquidMethylglyoxalDeoxyguanosine8-Hydroxy-2'-deoxyguanosineGlyoxalGeneral MedicineGlutathioneMiddle AgedPyruvaldehydeAscorbic acidGlutathioneEndocrinologychemistryBiochemistry8-Hydroxy-2'-DeoxyguanosineUric acidFemaleWerner SyndromeOxidation-ReductionOxidative stressFree Radical Research
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The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducin…

2007

Abstract Context: We previously showed that BAG3 protein, a member of the BAG (Bcl-2-associated athanogene) co-chaperone family, modulates apoptosis in human leukemias. The expression of BAG3 in other tumor types has not been extensively investigated so far. Objective: The objective of this study was to analyze BAG3 expression in thyroid neoplastic cells and investigate its influence in cell apoptotic response to TNF-related apoptosis-inducing ligand (TRAIL). Design, Setting, and Patients: We investigated BAG3 expression in human thyroid carcinoma cell lines, including NPA, and the effect of BAG3-specific small interfering RNA on TRAIL-induced apoptosis in NPA cells. Subsequently, we analyz…

medicine.medical_specialtySmall interfering RNAProgrammed cell deathEndocrinology Diabetes and MetabolismClinical BiochemistryApoptosisBiologyBiochemistryThyroid carcinomaTNF-Related Apoptosis-Inducing LigandEndocrinologyWestern blotInternal medicineCell Line TumormedicineHumansThyroid NeoplasmsRNA Small InterferingThyroid cancerAdaptor Proteins Signal Transducingmedicine.diagnostic_testDose-Response Relationship DrugBiochemistry (medical)ThyroidCarcinomamedicine.diseaseImmunohistochemistryEndocrinologymedicine.anatomical_structureApoptosisCancer researchTumor necrosis factor alphaApoptosis Regulatory Proteins
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