0000000000415152

AUTHOR

Marcos Otero-garcia

showing 3 related works from this author

Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear

2013

Fear memory circuits in the brain function to allow animals and humans to recognize putative sources of danger and adopt an appropriate behavioral response; and research on animal models of fear have helped reveal the anatomical and neurochemical nature of these circuits. The nucleus (n.) incertus in the dorsal pontine tegmentum provides a strong GABAergic projection to forebrain ‘fear centers’ and is strongly activated by neurogenic stressors. In this study in adult male rats, we examined the effect of electrolytic lesions of n. incertus on different stages of the fear conditioning-extinction process and correlated the outcomes with anatomical data on the distribution of n. incertus-derive…

MaleElectrolytic lesionConditioning ClassicalNerve Tissue ProteinsAmygdalaExtinction PsychologicalRats Sprague-DawleyBehavioral NeuroscienceS100 Calcium Binding Protein GPonsNeural PathwaysmedicineAnimalsFear conditioningHabituationFear memoryNeuronsFear processing in the brainBehavior AnimalRelaxinExtinctionFearExtinction (psychology)AmygdalaNucleus IncertusRatsFreezing behaviormedicine.anatomical_structureAcoustic StimulationCalbindin 2Relaxin-3PsychologyNucleus incertusNeuroscienceBasolateral amygdalaBehavioural Brain Research
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Distribution and targets of the relaxin-3 innervation of the septal area in the rat.

2012

Neural tracing studies have revealed that the rat medial and lateral septum are targeted by ascending projections from the nucleus incertus, a population of tegmental GABA neurons. These neurons express the relaxin-family peptide, relaxin-3, and pharmacological modulation of relaxin-3 receptors in medial septum alters hippocampal theta rhythm and spatial memory. In an effort to better understand the basis of these interactions, we have characterized the distribution of relaxin-3 fibers/terminals in relation to different septal neuron populations identified using established protein markers. Dense relaxin-3 fiber plexuses were observed in regions of medial septum containing hippocampal-proje…

MaleStilbamidinesPopulationHippocampusNerve Tissue ProteinsNitric Oxide Synthase Type IBiologyHippocampal formationCholine O-AcetyltransferaseRats Sprague-DawleyRelaxin-3 like-immunoreactivityMicroscopy Electron TransmissionNeural PathwaysmedicineAnimalseducationNeuronseducation.field_of_studyBrain MappingGlutamate DecarboxylaseGeneral NeuroscienceHippocampal theta rhythmRelaxinSeptal nucleiAnatomyNucleus IncertusCholine acetyltransferaseRatsSeptohippocampal systemmedicine.anatomical_structureParvalbuminsnervous systemStress and emotionSeptum of BrainNeuronNucleus incertusNucleusNeurosciencehormones hormone substitutes and hormone antagonistsThe Journal of comparative neurology
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Amygdala

2015

The amygdala is considered a key center in managing emotional information and its dysfunction is at the base of disorders ranging through anxiety, depression, PTSD and autism. However, the amygdala seems heterogeneous both structurally (with pallial and supallial components) and functionally. Thus, whereas cortical and thalamic multimodal sensory inputs enter the basolateral complex, the corticomedial amygdala is dominated by olfactory and vomeronasal inputs. Intrinsic amygdaloid circuitry, connects these two amygdaloid divisions and convey processed information to the main amygdala outputs. The pallial amygdala is the main source for telencephalic outputs to associative cortical areas (e.g…

Vomeronasal organVentral striatumHippocampusSensory systemmedicine.diseaseAmygdalamedicine.anatomical_structurenervous systemFrontal lobeExtended amygdalaExtinction (neurology)medicinePsychologyNeurosciencepsychological phenomena and processes
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