0000000000417375
AUTHOR
Tatsuro Yoneyama
Recent Advances in Kaempferia Phytochemistry and Biological Activity : A Comprehensive Review
Background: Plants belonging to the genus Kaempferia (family: Zingiberaceae) are distributed in Asia, especially in the southeast region, and Thailand. They have been widely used in traditional medicines to cure metabolic disorders, inflammation, urinary tract infections, fevers, coughs, hypertension, erectile dysfunction, abdominal and gastrointestinal ailments, asthma, wounds, rheumatism, epilepsy, and skin diseases. Objective: Herein, we reported a comprehensive review, including the traditional applications, biological and pharmacological advances, and phytochemical constituents of Kaempheria species from 1972 up to early 2019. Materials and methods: All the information and reported stu…
Two novel oxetane containing lignans and a new megastigmane from Paronychia arabica and in silico analysis of them as prospective SARS-CoV-2 inhibitors
The chemical characterization of the extract of the aerial parts of Paronychia arabica afforded two oxetane containing lignans, paronychiarabicine A (1) and B (2), and one new megastigmane, paronychiarabicastigmane A (3), alongside a known lignan (4), eight known phenolic compounds (5–12), one known elemene sesquiterpene (13) and one steroid glycoside (14). The chemical structures of the isolated compounds were constructed based upon the HRMS, 1D, and 2D-NMR results. The absolute configurations were established via NOESY experiments as well as experimental and TDDFT-calculated electronic circular dichroism (ECD). Utilizing molecular docking, the binding scores and modes of compounds 1–3 tow…
Cytotoxic polyoxygenated isopimarane diterpenoids from the edible rhizomes of Kaempferia galanga (kencur)
Abstract Kaempferia galanga (Family Zingiberaceae) is a widely distributed Asian medicinal plant and cultured crop. Several traditional uses of the rhizomes of this plant have been reported with widely using as flavors and spice in cooking. The present work concerned the isolation and identification as well as antiproliferative activity of metabolites of the rhizomes of K. galanga. Three new polyoxygenated isopimarane diterpenoids, kaemgalangols B-D (1-3), were isolated and identified in addition to 20 knowns (4-27), one monoterpene (28), and five known phenolic compounds (29-33). The chemical structures of the isolated compounds were established mainly based upon the spectroscopic analysis…
Two new diterpenoids from kencur (Kaempferia galanga): Structure elucidation and chemosystematic significance
Abstract Aromatic ginger or kencur (Kaempferia galanga L.) rhizomes are ground as a spice or pickled for consumption in south-east Asian cuisines; although widely used, until recently it has been less studied chemically than white and red ginger. Hydro-distillate extracts have identified several compounds that exhibit anticancer activity against select tumor cell lines in vitro, and most recently chemical analyses have focused on rhizome metabolites present in organic extracts. Here we report on two new diterpenoids including Δ8(14),15 polyhydroxlated isopimardienes, 1α-hydroperoxy-2α,6,7-trihydroxy-isopimara-6(7),8(14),15-triene (kaemgalangol E; 1) and 1α,7β-hydroxy-isopimara-8(14),15-dien…