6533b83afe1ef96bd12a7854

RESEARCH PRODUCT

Cytotoxic polyoxygenated isopimarane diterpenoids from the edible rhizomes of Kaempferia galanga (kencur)

Ningombam SwapanaNingombam SwapanaAkemi UmeyamaThomas A. EfferthAbdelsamed I. ElshamyTarik A. MohamedTatsuro YoneyamaMohamed-elamir F. HegazyMasaaki Noji

subject

0106 biological sciencesbiologyTraditional medicine010405 organic chemistryChemistryMonoterpenebiology.organism_classification01 natural sciences0104 chemical sciencesRhizomeKaempferia galangaIc50 valuesCytotoxic T cellZingiberaceaeAgronomy and Crop Science010606 plant biology & botany

description

Abstract Kaempferia galanga (Family Zingiberaceae) is a widely distributed Asian medicinal plant and cultured crop. Several traditional uses of the rhizomes of this plant have been reported with widely using as flavors and spice in cooking. The present work concerned the isolation and identification as well as antiproliferative activity of metabolites of the rhizomes of K. galanga. Three new polyoxygenated isopimarane diterpenoids, kaemgalangols B-D (1-3), were isolated and identified in addition to 20 knowns (4-27), one monoterpene (28), and five known phenolic compounds (29-33). The chemical structures of the isolated compounds were established mainly based upon the spectroscopic analysis such as FT-IR, 1D and 2D NMR, and HRMS. The antiproliferative activity of all isolates was screened against CCRF-CEM leukemia cells using a fixed concentration of 30 μM. Dose response curve of compounds 19 and 20 showed IC50 values of ≤ 50 μM against CCRF-CEM, MDAMB-231-pcDNA and HCT116 (p53+/+). Compound 20 showed the most potent activity against three tested cell lines with IC50 values of 35.28, 61.60, and 42.77 μM, respectively.

yearjournalcountryeditionlanguage
2020-12-01Industrial Crops and Products
https://doi.org/10.1016/j.indcrop.2020.112965